The Production Process of 4-[1-[(2S)-2-Aminopropyl]-1H-pyrazol-3-yl]-2-chlorobenzonitrile

4-[1-[(2S)-2-Aminopropyl]-1H-pyrazol-3-yl]-2-chlorobenzonitrile, also known as Fragolin, is a synthetic chemical compound that is commonly used as a pharmaceutical agent, research chemical, and recreational drug.
The production process of Fragolin involves several steps, including synthesis, purification, and formulation.
In this article, we will take a detailed look at the production process of Fragolin, including the major steps involved in the process and the equipment and chemicals required.

Step 1: Synthesis of 4-[1-[(2S)-2-Aminopropyl]-1H-pyrazol-3-yl]-2-chlorobenzonitrile

The synthesis of Fragolin involves several steps, including the synthesis of the base compound, 2-chlorobenzonitrile, and its further modification with the desired substituents.
The synthesis of 2-chlorobenzonitrile involves the reaction of chlorobenzene with nitrile in the presence of a Lewis acid catalyst, such as AlCl3.
The synthesis of the base compound typically involves the reaction of 2-chlorobenzene with a Grignard reagent followed by treatment with nitrile.

Step 2: Purification of 4-[1-[(2S)-2-Aminopropyl]-1H-pyrazol-3-yl]-2-chlorobenzonitrile

After the synthesis of Fragolin, the product is typically purified using a combination of chromatography and crystallization techniques.
The purification process is important to remove any impurities that may be present in the product, which can affect its efficacy and safety.
The purification process involves several steps, including:

• Solution chromatography: The crude product is dissolved in a suitable solvent and passed through a column packed with an inert solid support.
  The product is eluted from the column by gradually increasing the concentration of the eluting solvent.
  
• Fractional crystallization: The purified product is dissolved in a suitable solvent and allowed to crystallize slowly.
  The crystals are collected and dissolved in a solvent of appropriate polarity to obtain pure fractions.
  The pure fractions are then combined to obtain a pure product.
  

Step 3: Formulation of 4-[1-[(2S)-2-Aminopropyl]-1H-pyrazol-3-yl]-2-chlorobenzonitrile

After the purification of the product, it is typically formulated into a final product that can be used in its intended application.
The formulation process involves several steps, including:

• Drying: The purified product is dried thoroughly to remove any moisture that may be present.
  
• Milling: The dried product is milled to a fine powder to improve its flowability and mixability.
  
• Mixing: The milled product is mixed with appropriate excipients, such as lactose, to improve its solubility and stability.
  

Equipment and Chemicals Required

The production of Fragolin requires a variety of equipment and chemicals, including:

• Chemical reagents: Chlorobenzene, nitrile, Grignard reagents, and Lewis acid catalysts, such as AlCl3, are required for the synthesis of 2-chlorobenzonitrile.
  
• Chromatography equipment: A high-performance liquid chromatography (HPLC) system, a column packed with an inert solid support, and a solvent delivery system are required for solution chromatography.
  
• Crystallization equipment: A fractional crystallization tank and appropriate cooling and heating equipment are required for fractional crystallization.
  
• Formulation equipment: A mixing tank, a milling machine, and a drying oven are required for the formulation of the final product.
  

Conclusion

The production process of Fragolin