The Production Process of 3-Pyridinecarboxamide,5-hydroxy-(9CI)

3-Pyridinecarboxamide,5-hydroxy-(9CI) is an important intermediate in the chemical industry and is widely used in the production of various pharmaceuticals, agrochemicals, and other chemical products.
The production process of 3-pyridinecarboxamide,5-hydroxy-(9CI) involves several steps, which are outlined below.

1. Preparation of raw materials: The production of 3-pyridinecarboxamide,5-hydroxy-(9CI) starts with the preparation of raw materials, which includes the reaction of 3-pyridinecarboxaldehyde with sodium hydroxide to produce the corresponding sodium salt.
   
2. Condensation reaction: The sodium salt of 3-pyridinecarboxaldehyde is then condensed with 5-hydroxy-2-nitro-1,3-oxazole in the presence of a condensation agent such as dicyclohexylcarbodiimide (DCC) to form the desired product.
   
3. Deprotection: The product from the condensation reaction is then deprotected by treatment with a strong acid such as hydrochloric acid to remove the sodium salt and the protecting group.
   
4. Purification: The resulting product is then purified by crystallization, filtration, or chromatography.
   
5. Characterization: The purified product is then characterized by various analytical techniques such as spectroscopy, mass spectrometry, and chromatography to confirm its identity and purity.
   
6. Storage and transport: The final product is stored in a dry, airtight container in a cool, dry place, away from moisture, heat, and direct sunlight, and is transported in accordance with relevant regulations and guidelines.
   

In summary, the production process of 3-pyridinecarboxamide,5-hydroxy-(9CI) involves several steps, including the preparation of raw materials, condensation reactions, deprotection, purification, characterization, and storage and transport.
The entire process is carried out under controlled conditions to ensure the quality and purity of the final product.