The Production Process of 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester

The production process of 3-pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester, also known as pyridine-3-carboxylic acid, 6-chloro-,1-methylethyl ester, is a complex, multi-step process that involves several chemical reactions.
The synthesis of this compound is typically carried out in a laboratory setting, and the process can vary depending on the desired yield and purity of the final product.

The starting materials for the production of 3-pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester include pyridine-3-carboxaldehyde, 1,1-dimethylethyl 7-azaindole-2-carboxylate, and 2,2'-iminodiisonitrile.
These materials are then placed in a reaction vessel, along with solvents such as acetonitrile and water, and the reaction is catalyzed by a Lewis acid catalyst, such as zinc chloride.

The first step in the production process is the condensation of pyridine-3-carboxaldehyde and 1,1-dimethylethyl 7-azaindole-2-carboxylate, which results in the formation of a imine.
This imine is then reduced with 2,2'-iminodiisonitrile, which results in the formation of a amine.
The Lewis acid catalyst is used to catalyze this reaction, and it is typically added in small amounts to the reaction mixture.

The next step in the production process is the esterification of the amine with 1-methylethyl chloride.
This reaction is carried out in the presence of a solvent, such as acetonitrile, and a base, such as sodium hydroxide.
This reaction results in the formation of pyridine-3-carboxylic acid, 6-chloro-,1-methylethyl ester.

After the esterification reaction is complete, the mixture is typically filtered to remove any solid impurities, and the solvent is removed by evaporation.
The resulting residue is then purified by a variety of methods, such as recrystallization, chromatography, or precipitation.

The final product is a white, powdery solid that is typically stored under an inert gas atmosphere, such as nitrogen, to prevent oxidation.
The purity of the final product can be determined by various analytical techniques, such as spectroscopy or chromatography.

In conclusion, the production process of 3-pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester is a multi-step synthesis that involves several chemical reactions.
The synthesis of this compound is typically carried out in a laboratory setting, and the process can vary depending on the desired yield and purity of the final product.
The production process involves several steps such as condensation, reduction, esterification and purification.
The final product is a white, powdery solid that is typically stored under an inert gas atmosphere.
The purity of the final product can be determined by various analytical techniques, such as spectroscopy or chromatography.