The Production Process of (3-exo)-3-[3-Methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-(phenylmethyl)-8-azabicyclo[3.2.1]octane

The production process of (3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-(phenylmethyl)-8-azabicyclo[3.
2.
1]octane, also known as R218, is a complex and multi-step process that involves several chemical reactions and purification steps.
This article will provide a detailed overview of the production process of R218, including the raw materials required, the various chemical reactions involved, and the purification steps necessary to obtain the final product.

Raw materials and starting materials

The production of R218 starts with the synthesis of the starting material, which is tetrabutylammonium iodide.
This compound is reacted with 3-methyl-5-(1-methylethyl)-4H-1,2,4-triazole to form the intermediate compound (3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-(phenylmethyl)-8-azabicyclo[3.
2.
1]octane.

Chemical reactions involved in the production process

The production process of R218 involves several chemical reactions, including the following:

1. Synthesis of tetrabutylammonium iodide: Tetrabutylammonium iodide is synthesized by reacting tetrabutylammonium hydroxide with iodine in the presence of a solvent such as water or methanol.
   
2. Reaction of tetrabutylammonium iodide with 3-methyl-5-(1-methylethyl)-4H-1,2,4-triazole: Tetrabutylammonium iodide is reacted with 3-methyl-5-(1-methylethyl)-4H-1,2,4-triazole in the presence of a base such as sodium hydroxide or potassium hydroxide.
   This reaction forms the intermediate compound (3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-(phenylmethyl)-8-azabicyclo[3.
   2.
   1]octane.
   
3. Purification of the intermediate compound: The intermediate compound is purified through a series of steps, including crystallization, washing with solvents such as ethanol or hexane, and recrystallization.
   
4. Hydrogenation of the intermediate compound: The intermediate compound is hydrogenated to remove any remaining impurities and to increase its purity.
   

Purification and characterization of the final product

After the hydrogenation step, the final product is obtained.
The purity of the final product is determined through various analytical techniques, including spectroscopy, chromatography, and mass spectrometry.
The identity and purity of the final product are also confirmed through chemical reactions and elemental analysis.

Quality control and stability studies

To ensure the quality and stability of the final product, various quality control tests are performed, includingTests, including