The Production Process of 3-Chloro-6-phenyl-pyridazin-4-ol

The production process of 3-chloro-6-phenyl-pyridazin-4-ol, a synthetic organic compound, involves several steps that are carried out in a laboratory setting.
The following is an overview of the production process of 3-chloro-6-phenyl-pyridazin-4-ol.

Step 1: Preparation of Benzonitrile
The first step in the production process of 3-chloro-6-phenyl-pyridazin-4-ol is the preparation of benzonitrile, a key starting material.
Benzonitrile is prepared by the hydrolysis of benzotrifluoride in the presence of water and a strong acid catalyst, such as sulfuric acid.
The reaction is carried out in a reaction flask equipped with a stirrer, thermometer, and a condenser.
The reaction mixture is heated to about 100-150°C and stirred for several hours.
The resulting benzonitrile is collected and purified by distillation.

Step 2: Chlorination of Benzonitrile
The next step is the chlorination of benzonitrile to form 2-chlorobenzonitrile.
This is carried out by treating benzonitrile with chlorine gas in the presence of a catalyst, such as ferric chloride.
The reaction is carried out in a reaction flask equipped with a stirrer and a thermometer.
The reaction mixture is heated to about 50-70°C and stirred for several hours.
The resulting 2-chlorobenzonitrile is collected and purified by distillation.

Step 3: Preparation of (R)-(-)-1-Aminocyclohexan-2-ol
The next step is the preparation of (R)-(-)-1-aminocyclohexan-2-ol, a key intermediate in the production of 3-chloro-6-phenyl-pyridazin-4-ol.
This is achieved by treating (R)-(-)-1-amino-2-butanone with sodium hydroxide in the presence of a solvent, such as methanol.
The reaction is carried out in a reaction flask equipped with a stirrer, thermometer, and a condenser.
The reaction mixture is heated to about 70-80°C and stirred for several hours.
The resulting (R)-(-)-1-aminocyclohexan-2-ol is collected and purified by hydrochloric acid treatment.

Step 4: Nitration of (R)-(-)-1-Aminocyclohexan-2-ol
The next step is the nitration of (R)-(-)-1-aminocyclohexan-2-ol to form (R)-(-)-1-amino-2-nitropropan-2-ol.
This is carried out by treating (R)-(-)-1-aminocyclohexan-2-ol with nitric acid in the presence of a solvent, such as water.
The reaction is carried out in a reaction flask equipped with a stirrer, thermometer, and a condenser.
The reaction mixture is heated to about 80-90°C and stirred for several hours.
The resulting (R)-(-)-1-amino-2-nitropropan-2-ol is collected and purified by hydrochloric acid treatment.

Step 5: Condensation of (R)-(-)-1-Amino-2-nitropropan-2-ol and 3-Chloro-6-phenyl-pyridazin-4-ol
The final step is the condensation of (R)-(-)-1-amino-2-nitropropan-2-ol and 3-chloro-6-phenyl-pyridazin-4-ol to form the target compound, 3-