The Production Process of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine, 98+% C9H11Cl2N3, MW: 232.11

The Production Process of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine in Chemical Industry

3-chloro-6-(4-chloropiperidin-1-yl)pyridazine is a versatile compound used in various applications in the chemical industry.
Its unique structure and properties make it a valuable building block for the synthesis of various chemicals, drugs, and other products.
The production process of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine involves several steps, which are outlined below.

Step 1: Preparation of the Starting Materials
The production of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine begins with the preparation of the starting materials.
The reaction involves the condensation of 4-chloropiperidine with 3-chlorPyridazine in the presence of a strong acid catalyst such as hydrochloric acid.
This reaction is exothermic and requires careful monitoring to avoid excessive heating.
The reaction mixture is then allowed to cool to room temperature before the next step.

Step 2: Recrystallization
The product obtained from the condensation reaction is a solid with a high molecule weight.
To obtain a purer and more soluble form of the product, the solid is recrystallized using a suitable solvent such as ethanol or methanol.
The recrystallization process involves dissolving the solid in the solvent, allowing it to cool, and then allowing the crystals to form through slow evaporation.
The crystals are then collected and dried to obtain a pure sample of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine.

Step 3: Purification by Chromatography
To obtain a highly pure sample of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine, the purified crystals are subjected to chromatography.
The sample is dissolved in a suitable solvent, and then passed through a column packed with an inert solid.
The solvent moves through the column at a controlled rate, and the component molecules are separated based on their size andshape.
The desired product elutes out of the column first, and can be collected and concentrated to obtain a highly pure sample.

Step 4: Characterization of the Product
The final step in the production process is the characterization of the product.
This involves determining the chemical properties of the product, such as its molecular weight, structure, and purity.
This can be done using various techniques such as nuclear magnetic resonance spectroscopy (NMR), mass spectrometry, and X-ray crystallography.
The product is also tested for its stability and shelf life to ensure that it meets the required standards.

Conclusion
The production process of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine involves several steps, each of which is critical to obtaining a high-quality product.
The steps include the preparation of starting materials, recrystallization, purification by chromatography, and characterization of the product.
These steps require careful monitoring and control to ensure that the product meets the desired specifications.
The use of 3-chloro-6-(4-chloropiperidin-1-yl)pyridazine as a building block for the synthesis of other chemicals underscores its importance in the chemical industry.