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The production process of 3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazine, 98+% C10H13Cl2N3, MW: 246.
14, is a complex and multi-step process that involves several chemical reactions and purification steps.
The final product is an organic compound with a molecular weight of 246.
14, which is used in various applications in the chemical industry.
In this article, we will discuss the production process of 3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazine in detail.
Step 1: Synthesis of 1-(3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazin-4-yl)propan-2-ol
The first step in the production process of 3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazine is the synthesis of 1-(3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazin-4-yl)propan-2-ol.
This compound is synthesized by reacting 1-[(4-bromo-2-oxo-1,3-oxazolidin-3-yl)methyl]-4,5-dihydroimidazole with 3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridine in the presence of a catalyst, such as cesium carbonate.
The reaction is carried out at a temperature of 80-100°C for several hours, followed by filtering and washing with a solvent, such as ethyl acetate, to remove any impurities.
Step 2: Synthesis of 4-(3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazin-1-yl)butan-2-ol
The next step in the production process of 3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazine is the synthesis of 4-(3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazin-1-yl)butan-2-ol.
This compound is synthesized by reacting 4-bromo-1-butanol with 1-(3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazin-4-yl)propan-2-ol in the presence of a catalyst, such as sodium hydroxide.
The reaction is carried out at a temperature of 80-100°C for several hours, followed by filtering and washing with a solvent, such as ethyl acetate, to remove any impurities.
Step 3: Synthesis of 3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazine
The final step in the production process of 3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazine is the synthesis of the final product.
This is achieved by reacting 4-(3-chloro-6-(3-(chloromethyl)piperidin-1-yl)pyridazin-1-yl)butan-2-ol with 3-chloro-1-methyl-2-pyrrolidinone in the presence of a catalyst, such as pyridine.
The reaction is carried out at a temperature of 80-1
