The Production Process of 3-Chloro-6-(3-chloro-1-piperidinyl)pyridazine

The Production Process of 3-Chloro-6-(3-chloro-1-piperidinyl)pyridazine

3-Chloro-6-(3-chloro-1-piperidinyl)pyridazine, also known as Tranylcypromine, is a chemical compound that has been utilized for various purposes in the chemical industry, including as a pharmaceutical intermediate and as a reagent in organic synthesis.
The production process of this compound involves several steps, including the preparation of starting materials, the execution of chemical reactions, and the isolation and purification of the final product.

Preparation of Starting Materials

The production of 3-chloro-6-(3-chloro-1-piperidinyl)pyridazine begins with the preparation of starting materials.
The first step involves the synthesis of 3-chloro-1-piperidine, which is then reacted with another compound to form 6-(3-chloro-1-piperidinyl)pyridazine.
The final step in the preparation of starting materials involves the reaction of 6-(3-chloro-1-piperidinyl)pyridazine with chloroform to form 3-chloro-6-(3-chloro-1-piperidinyl)pyridazine.

Chemical Reactions

The next step in the production process of 3-chloro-6-(3-chloro-1-piperidinyl)pyridazine is the execution of chemical reactions to convert the starting materials into the final product.
This involves the use of various chemical reagents, such as hydrogen chloride, sodium hydroxide, and sodium chloride, in addition to solvents like water and ether.
The specific reaction conditions, such as temperature and pressure, may vary depending on the specific process used by the manufacturer.

Isolation and Purification

After the completion of the chemical reactions, the final product, 3-chloro-6-(3-chloro-1-piperidinyl)pyridazine, must be isolated and purified from the reaction mixture.
This involves the use of various techniques, such as filtration, crystallization, and chromatography, to separate the desired product from any impurities that may be present.
The purity of the final product is crucial, as it determines its suitability for use in various applications.

Chromatography is a common technique used in the purification of 3-chloro-6-(3-chloro-1-piperidinyl)pyridazine.
In this process, the reaction mixture is passed through a column packed with a stationary phase, such as silica gel or alumina, and the compound of interest is separated from the other components based on its properties, such as size and charge.
The purified product is then collected and dried, and the residual solvent is removed to obtain the final, pure product.

Conclusion

The production of 3-chloro-6-(3-chloro-1-piperidinyl)pyridazine requires careful planning and execution, and the success of the process depends on the quality of the starting materials and the efficiency of the purification process.
The specific production process may vary depending on the manufacturer, but the general steps involved, including the preparation of starting materials, execution of chemical reactions, and isolation and purification of the final product, remain the same.
The final product is then packaged and shipped to customers for use in various applications in the chemical industry.

References

1. "3-Chloro-6-(3-chloro-1-piperidinyl)pyridazine.
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