The Production Process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile

The production process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile, a versatile organic compound with a wide range of applications in the chemical industry, involves several steps that require careful attention to details.
The following is a comprehensive overview of the production process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile.

Step 1: Preparation of the starting materials
The production of 3,5-bis-benzyloxy-pyridine-2-carbonitrile begins with the preparation of the starting materials, which involves the synthesis of 2-aminopyridine and 4-chloro-3-nitropyridine.
The 2-aminopyridine can be synthesized by a variety of methods, including the reduction of 2-benzyloxy-pyridine using hydrogen gas in the presence of a catalyst, such as palladium on barium carbonate.
The 4-chloro-3-nitropyridine, on the other hand, can be synthesized by treating pyridine-3-carboxaldehyde with chloroform and sodium hydroxide, followed by reduction with hydrogen gas.

Step 2: Condensation of the starting materials
The next step in the production process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile is the condensation of the starting materials, which involves the reaction of 2-aminopyridine and 4-chloro-3-nitropyridine in the presence of a condensation agent, such as dicyclohexylcarbodiimide (DCC), and a solvent, such as dimethylformamide (DMF).
This reaction results in the formation of a mixture of nitro and amino compounds, which are then purified by crystallization or chromatography.

Step 3: Cyclization of the mixture
The next step in the production process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile is the cyclization of the mixture of nitro and amino compounds, which involves the reaction of the mixture with sodium hydroxide in a solvent, such as ethanol.
This reaction results in the formation of 3,5-bis-benzyloxy-pyridine-2-carbonitrile, which can be isolated by filtration and washed with water.

Step 4: Purification of the product
The final step in the production process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile is the purification of the product, which involves the removal of any impurities that may have been introduced during the previous steps.
This can be achieved by recrystallization, chromatography, or other appropriate methods.

In conclusion, the production process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile involves several steps that require careful attention to details.
The production process outlined above provides a general overview of the steps involved in the production of 3,5-bis-benzyloxy-pyridine-2-carbonitrile, and the specific steps and conditions may vary depending on the scale and purity requirements of the final product.
Nonetheless, the production process of 3,5-bis-benzyloxy-pyridine-2-carbonitrile serves as a starting point for the development of new organic compounds and their applications in a wide range of industrial and commercial applications.