The Production Process of 3-((3,5-Bis(trifluoromethyl)phenethoxy)(4-fluorophenyl)(morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one

The 3-((3,5-Bis(trifluoromethyl)phenethoxy)(4-fluorophenyl)(morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one, also known as GSK2130067, is a pharmaceutical compound that is currently being investigated for its potential therapeutic applications.
The production process of GSK2130067 involves several steps, which are carried out in a laboratory setting.
The following is an overview of the production process of GSK2130067.

Step 1: Synthesis of 3-((3,5-Bis(trifluoromethyl)phenethoxy)acetamide
The first step in the production process of GSK2130067 involves the synthesis of 3-((3,5-Bis(trifluoromethyl)phenethoxy)acetamide.
This compound is synthesized by reacting 3,5-bis(trifluoromethyl)phenol with acetyl chloride in the presence of a solvent such as dichloromethane.
The reaction is then catalyzed by a weak acid catalyst such as imidazole.
The resulting product is then purified by chromatography to remove any impurities.

Step 2: Synthesis of 4-Fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)acetamide
In this step, 4-fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)acetamide is synthesized by reacting 4-fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)amide with HCl in the presence of a solvent such as ether.
The resulting product is then purified by chromatography to remove any impurities.

Step 3: Synthesis of 4-Fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)(morpholino)methyl)amide
In this step, 4-fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)(morpholino)methyl)amide is synthesized by reacting 4-fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)amide with morpholine in the presence of a solvent such as DMF.
The resulting product is then purified by chromatography to remove any impurities.

Step 4: Synthesis of 4-Fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)(morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
The final step in the production process of GSK2130067 involves the synthesis of the final product, 4-Fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)(morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one.
This compound is synthesized by reacting 4-fluoro-3-((3,5-Bis(trifluoromethyl)phenethoxy)(morpholino)methyl)amide with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and hydroxybenzotriazole (HOBT) in the presence of a solvent such as DMF.
The resulting product is then purified by chromatography to remove any impurities.

Conclusion
The production process of GSK2130067 involves several steps, which are carried out in a laboratory setting.
The compound is synthesized by reacting several starting materials and purifying the resulting products