The Production Process of (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

The production process of (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine is a complex and multi-step process that involves several chemical reactions and purification steps.
The following is an overview of the production process of this compound in the chemical industry.

Step 1: Synthesis of 3,5-Bis(trifluoromethyl)phenylamine
The synthesis of 3,5-Bis(trifluoromethyl)phenylamine is the first step in the production process of (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine.
The synthesis of 3,5-Bis(trifluoromethyl)phenylamine can be accomplished by several methods, including the reaction of 2,6-difluorobenzaldehyde with sodium hydride in the presence of a solvent such as N,N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO).
The resulting 3,5-Bis(trifluoromethyl)phenylamine can be isolated by filtration and washed with water.

Step 2: Protection of the Amine Functionality
The next step in the production process of (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine is the protection of the amine functionality of 3,5-Bis(trifluoromethyl)phenylamine.
This can be accomplished by treating the amine with a protecting group such as tert-butyl iodide or benzyl bromide.
The protected amine can be isolated by filtration and washed with a solvent such as ether or hexane.

Step 3: Reaction with Ethyl 2-[(1S)-1-(4-Fluorophenyl)ethoxy]-2-Methylpropionate
The protected amine is then reacted with ethyl 2-[(1S)-1-(4-fluorophenyl)ethoxy]-2-methylpropionate in the presence of a solvent such as dichloromethane or chloroform.
The resulting product can be isolated by filtration and washed with ether or hexane.

Step 4: Deprotection and Purification
The next step in the production process of (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine is the deprotection of the amine functionality.
This can be accomplished by treating the product from the previous step with a solvent such as hydrochloric acid or a combination of hydrochloric acid and dioxane.
The resulting (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine can be isolated by filtration and washed with water.

Step 5: Purification
The final step in the production process of (2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine is the purification of the compound.
This can be accomplished by several methods, including chromatography on a silica gel column or a reverse phase column.
The resulting (2S,3R)-2-[(1S)-1