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The production process of [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphinic acid involves several steps, including the preparation of starting materials, reaction setup, reaction optimization, and final product purification.
In the chemical industry, the production process is a critical step in ensuring the quality and efficiency of the final product.
Starting Materials Preparation
The production of [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphinic acid requires several starting materials, including 6-aminopurine, propan-2-ol, and a phosphinic acid.
The preparation of these starting materials is the first step in the production process.
The preparation of 6-aminopurine typically involves the reaction of hydroxyanthracene-9-sulfonic acid with ammonia.
The reaction produces a mixture of isomers, which must be separated using chromatographic techniques, such as high-performance liquid chromatography (HPLC).
The purified 6-aminopurine is then used as a starting material in the production of [(2R)-1-(6-aminopurin-
