The Production Process of (2E)-3-[4-(METHYLSULFONYL)PHENYL]PROPENOIC ACID

(2E)-3-[4-(Methylsulfonyl)phenyl]propanoic acid, also known as Methyl 4-[[2-[(4S)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]benzoate, is a synthetic compound that can be found in some medications used to treat skin conditions such as eczema and psoriasis.
The production process of (2E)-3-[4-(METHYLSULFONYL)PHENYL]PROPENOIC ACID is a multi-step process involving several chemical reactions and purification steps.

Step 1: Synthesis of the starting material
The first step in the production of (2E)-3-[4-(Methylsulfonyl)phenyl]propanoic acid involves the synthesis of the starting material, which is the 2-[(4S)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-ylamine.
This compound can be synthesized using known chemical reactions such as Suzuki coupling, Stille coupling, or Horner-Emmons reaction.
The exact method used will depend on the availability of the starting materials, the desired yield, and the purity of the final product.

Step 2: Condensation reaction
The next step in the production of (2E)-3-[4-(Methylsulfonyl)phenyl]propanoic acid is a condensation reaction, where the 2-[(4S)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-ylamine is reacted with a suitable acid chloride, such as methyl sulfonic acid chloride, to form the corresponding amide.
This reaction is typically carried out in the presence of a solvent such as dichloromethane, and the reaction is typically carried out under conditions that allow for the formation of the desired product.

Step 3: Hydrolysis
The next step in the production of (2E)-3-[4-(Methylsulfonyl)phenyl]propanoic acid is the hydrolysis of the amide formed in the previous step.
This is typically carried out by treating the amide with water and a suitable catalyst, such as sodium hydroxide or hydrochloric acid.
The reaction is typically carried out in the presence of a solvent such as ethanol, and the conditions used will depend on the specific reactants and the desired product.

Step 4: Purification
The final step in the production of (2E)-3-[4-(Methylsulfonyl)phenyl]propanoic acid is the purification of the resulting product.
This can be done using a variety of methods, such as crystallization, chromatography, or filtration.
The exact method used will depend on the purity of the final product and the desired end-use application.

Overall, the production process of (2E)-3-[4-(Methylsulfonyl)phenyl]propanoic acid is a multi-step process that involves several chemical reactions and purification steps.
The exact conditions used for each step will depend on the specific reactants and the desired product.
The final product is a synthetic compound that can be used to treat skin conditions such as eczema and psoriasis.