The Production Process of 2-Tert-butylpyrimidin-4-amine

The production process of 2-tert-butylpyrimidin-4-amine involves several stages, from the initial preparation of the starting materials to the final product.
The following is a detailed overview of the production process of 2-tert-butylpyrimidin-4-amine.

Stage 1: Preparation of the starting materials
The production of 2-tert-butylpyrimidin-4-amine begins with the preparation of the starting materials, which include 2,4-diaminotoluene and β-alanine.
2,4-diaminotoluene is prepared by a conventional nitration process, which involves the reaction of toluene with nitric acid to produce 2,4-dinitro-toluene.
This compound is then reduced using hydrogen in the presence of a nickel catalyst to produce 2,4-diaminotoluene.

β-alanine is prepared by a similar process, which involves the reaction of cyanic acid with alcohol in the presence of a base catalyst.
This reaction produces β-alanine, which is then purified by recrystallization.

Stage 2: Condensation reaction
The next step in the production of 2-tert-butylpyrimidin-4-amine involves the condensation of 2,4-diaminotoluene and β-alanine to produce 2-triamino-3-oxobutane.
This reaction is carried out in the presence of a strong acid catalyst, such as sulfuric acid, and results in the formation of a double amide.

Stage 3: Reduction of the double amide
The double amide produced in the condensation reaction is reduced using hydrogen in the presence of a metal catalyst, such as palladium on barium oxide, to produce 2-triamino-2,3-dihydro-1H-pyrimidin-4-amine.

Stage 4: Nitration of the amine
The final step in the production of 2-tert-butylpyrimidin-4-amine involves the nitration of the amine produced in the reduction reaction.
This involves the reaction of the amine with nitric acid in the presence of a nitrating agent, such as oxygen or hydrogen peroxide, to produce the final product.

Stage 5: Purification and isolation of the product
The final step in the production of 2-tert-butylpyrimidin-4-amine involves the purification and isolation of the product.
This is typically achieved by crystallization, which results in the formation of pure crystals of the desired product.

In summary, the production process of 2-tert-butylpyrimidin-4-amine involves several stages, from the preparation of the starting materials to the final product.
These stages include the preparation of 2,4-diaminotoluene and β-alanine, the condensation of these compounds to produce a double amide, the reduction of the double amide to produce 2-triamino-2,3-dihydro-1H-pyrimidin-4-amine, the nitration of the amine to produce the final product, and the purification and isolation of the product.