The Production Process of 2-CYANOPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

The production process of 2-cyanopyrimidine-5-boronic acid pinacol ester involves a series of chemical reactions that convert raw materials into the desired product.
The process can be broken down into several steps, each of which requires careful control of temperature, pressure, and other conditions to ensure maximum efficiency and yield.

Step 1: Preparation of the boronic acid

The first step in the production process of 2-cyanopyrimidine-5-boronic acid pinacol ester involves the preparation of the boronic acid.
This is typically done by reacting boric acid with a suitable organic compound, such as cinnamaldehyde or hydroxybenzaldehyde, in the presence of a Lewis acid catalyst, such as aluminum chloride or boron trifluoride.
The reaction is typically carried out in an inert solvent, such as toluene or xylene, at a temperature of around 80-100°C.

Step 2: Condensation of the boronic acid with the pinacol ester

The next step in the production process of 2-cyanopyrimidine-5-boronic acid pinacol ester involves the condensation of the boronic acid with the pinacol ester.
This is typically done by heating the boronic acid and the pinacol ester in the presence of a condensation agent, such as triphenylphosphine or pyridine, at a temperature of around 150-180°C.
The reaction is typically carried out in an inert solvent, such as dichloromethane or chloroform.

Step 3: Cyclization of the intermediate compound

The third step in the production process of 2-cyanopyrimidine-5-boronic acid pinacol ester involves the cyclization of the intermediate compound.
This is typically done by heating the intermediate compound in the presence of a catalyst, such as cesium carbonate or potassium hydroxide, at a temperature of around 120-140°C.
The reaction is typically carried out in an inert solvent, such as acetonitrile or DMF.

Step 4: Deprotection of the pinacol ester

The final step in the production process of 2-cyanopyrimidine-5-boronic acid pinacol ester involves the deprotection of the pinacol ester.
This is typically done by treating the pinacol ester with a strong acid, such as hydrochloric acid or sulfuric acid, at a temperature of around 0-10°C.
The reaction is typically carried out in an inert solvent, such as water or ether.

Overall, the production process of 2-cyanopyrimidine-5-boronic acid pinacol ester involves a series of chemical reactions that convert raw materials into the desired product.
The process requires careful control of temperature, pressure, and other conditions to ensure maximum efficiency and yield.
The product can be used in various applications in the chemical industry, including as a building block for the synthesis of pharmaceuticals, agrochemicals, and other products.