The Production Process of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide

2-Chloro-N-ethyl-N-phenylpyridine-4-carboxamide is a chemical compound that is commonly used in various industrial processes.
It is synthesized through a multi-step process that involves several chemical reactions and purification steps.
In this article, we will discuss the production process of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide in detail.

Step 1: Synthesis of N-ethyl-N-phenylpyridine-4-carboxaldehyde
The first step in the production of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide is the synthesis of N-ethyl-N-phenylpyridine-4-carboxaldehyde.
This compound is synthesized by reacting N-ethyl-N-phenyl-p-aminobenzoic acid with pyridine-4-carboxaldehyde in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction is exothermic, and the reaction mixture is stirred at room temperature for several hours to ensure complete reaction.
The resulting product is then purified by dissolving it in water and extracting it with ethyl acetate.
The organic layer is then washed with brine and dried with sodium sulfate before being filtered and concentrated.

Step 2: Synthesis of 2-chloro-N-ethyl-N-phenylpyridine-4-amine
The next step in the production of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide is the synthesis of 2-chloro-N-ethyl-N-phenylpyridine-4-amine.
This compound is synthesized by reacting N-ethyl-N-phenyl-p-aminobenzoic acid with 2-chlorpyridine in the presence of a strong base catalyst, such as sodium hydroxide.
The reaction is carried out in a nitrogen atmosphere, and the reaction mixture is stirred at room temperature for several hours to ensure complete reaction.
The resulting product is then purified by dissolving it in water and extracting it with ethyl acetate.
The organic layer is then washed with brine and dried with sodium sulfate before being filtered and concentrated.

Step 3: Synthesis of 2-chloro-N-ethyl-N-(2-chlorophenyl)pyridine-4-carboxamide
The final step in the production of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide is the synthesis of 2-chloro-N-ethyl-N-(2-chlorophenyl)pyridine-4-carboxamide.
This compound is synthesized by reacting 2-chloro-N-ethyl-N-phenylpyridine-4-amine with 2-chlorophenyl isocyanate in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction is exothermic, and the reaction mixture is stirred at room temperature for several hours to ensure complete reaction.
The resulting product is then purified by dissolving it in water and extracting it with ethyl acetate.
The organic layer is then washed with brine and dried with sodium sulfate before being filtered and concentrated.

Overall, the production process of 2-chloro-N-ethyl-N-phenylpyridine-4-carboxamide involves several chemical reactions and purification steps.
The compound is synthesized through a multi-step process that involves the synthesis of N-ethyl-N-phenylpyridine-4-carboxalde