The Production Process of 2-Chloro-4-(ethoxymethyl)pyrimidine

The production process of 2-chloro-4-(ethoxymethyl)pyrimidine, commonly referred to as CEP, is a complex and multi-step process that involves several chemical reactions and purification steps.
CEP is an organic compound that is widely used in the production of pharmaceuticals, agrochemicals, and other chemical products.
In this article, we will discuss the production process of CEP in detail.

Step 1: Production of 4-Ethoxymethyl-2-chloroaniline
The first step in the production of CEP is the production of 4-ethoxymethyl-2-chloroaniline, which is also known as EMOCA.
This compound is synthesized by reacting 2-chloroaniline with ethylene oxide in the presence of a catalyst, such as sodium hydroxide.
The reaction is carried out at high temperatures and pressures, and the resulting product is then cooled and neutralized with acid.

Step 2: Production of N-Ethoxycarbonyl-2-chloro-4-methyl-6- ethoxy-1,3-oxazepanecarboxamide
The next step in the production of CEP is the production of N-ethoxycarbonyl-2-chloro-4-methyl-6-ethoxy-1,3-oxazepanecarboxamide, which is also known as N-EMOCA.
This compound is synthesized by reacting EMOCA with carbon dioxide in the presence of a catalyst, such as sulfuric acid.
The reaction is carried out at high temperatures and pressures, and the resulting product is then purified by dissolving it in water and extracting with organic solvents.

Step 3: Production of N-Ethoxycarbonyl-2-chloro-4-(ethoxymethyl)pyrimidine
The final step in the production of CEP is the production of N-ethoxycarbonyl-2-chloro-4-(ethoxymethyl)pyrimidine, which is also known as N-CEP.
This compound is synthesized by reacting N-EMOCA with CEP in the presence of a catalyst, such as hydrochloric acid.
The reaction is carried out at high temperatures and pressures, and the resulting product is then purified by dissolving it in water and extracting with organic solvents.

Purification and Characterization of CEP
After the production process is complete, the CEP is purified and characterized to ensure its quality and purity.
This involves several steps, including dissolving the compound in water and extracting with organic solvents, filtering the solution, and then recrystallizing the resulting solid.
The crystals are then dried and characterized using techniques such as spectroscopy and chromatography.

Conclusion
The production process of CEP is a complex and multi-step process that involves several chemical reactions and purification steps.
The compound is widely used in the production of pharmaceuticals, agrochemicals, and other chemical products.
The process can be challenging and requires careful attention to details and precise control of the reaction conditions.
However, with the right equipment and expertise, CEP can be produced in large quantities with high purity and quality.