The Production Process of 2-Bromo-N,N-dipropylbenzenesulphonamide

2-Bromo-N,N-dipropylbenzenesulphonamide, also known as TBP-2, is a commonly used solvent in the chemical industry.
It is widely used in the extraction of valuable substances from various organic and inorganic matrices.
The production process of TBP-2 involves several steps, which are briefly described below.

Step 1: Preparation of N,N-dipropylaniline
The first step in the production of TBP-2 involves the preparation of N,N-dipropylaniline.
This compound is synthesized by the reaction of propylene diamine with nitrous acid.
The reaction is carried out in the presence of a solvent, such as acetonitrile or dimethylformamide, and a catalyst, such as hydrochloric acid or sulfuric acid.

Step 2: N-Bromosuccinimide (NBS)
In this step, N-bromosuccinimide (NBS) is added to a mixture of N,N-dipropylaniline and hydrogen bromide.
Hydrogen bromide is generated by the reaction of bromine with sodium hydroxide.
The reaction takes place in the presence of a solvent, such as acetonitrile or benzene.

Step 3: Recrystallization
The resulting mixture is then subjected to recrystallization to purify the product.
Recrystallization involves dissolving the crude product in a solvent, such as benzene or toluene, and allowing the solvent to slowly evaporate.
The resulting crystals are then collected and dried to obtain pure N,N-dipropyl-2-bromobenzenesulfonamide.

Step 4: Condensation
The purified N,N-dipropyl-2-bromobenzenesulfonamide is then condensed with another batch of N,N-dipropyl-2-bromobenzenesulfonamide to increase the yield.
The condensation reaction takes place in the presence of a condensation agent, such as pyridine or triethylamine, and a solvent, such as benzene or toluene.

Step 5: Purification
The resulting condensate is then subjected to purification to remove any impurities.
This is typically done by dissolving the condensate in a solvent, such as benzene or toluene, and then precipitating the pure product by adding a nonsolvent, such as ether or hexane.

Step 6: Recrystallization
The resulting precipitate is then subjected to recrystallization to further purify the product.
This is typically done by dissolving the precipitate in a solvent, such as benzene or toluene, and then allowing the solvent to slowly evaporate.
The resulting crystals are then collected and dried to obtain pure TBP-2.

Overall, the production process of TBP-2 involves several steps that require careful control of temperature, pressure, and the choice of reaction conditions.
Each step is essential to ensure the purity and quality of the final product, which is used as a solvent in a variety of applications in the chemical industry.