The Production Process of 2-amino-9-(2-hydroxyethyl)-3H-purin-6-one

The production process of 2-amino-9-(2-hydroxyethyl)-3H-purin-6-one, also known as 2,9-bis(2-hydroxyethylamino)-1,3:2,4-dibenzo[d,f][1,4]benzoxazepine, is a complex and multi-step process that involves several chemical reactions and purification steps.
The compound is used in various applications, including as a corrosion inhibitor, a metal chelator, and a biodegradable plasticizer.

To manufacture 2-amino-9-(2-hydroxyethyl)-3H-purin-6-one, the first step is to synthesize 2-amino-9-(2-hydroxyethyl)amino-6-oxo-5H-benzo[b]thiophene-3-one.
This compound is synthesized by reacting 2-amino-9-(2-hydroxyethyl)amino-7-bromo-3H-purin-6-one with sodium hydride in a mixture of dimethylformamide and dimethylsulfoxide.
The reaction is carried out at a temperature of about 80-100°C for several hours, until the reaction is complete.

The next step in the production process is to reduce the nitro group of the synthesized compound to obtain 2-amino-9-(2-hydroxyethyl)amino-6-oxo-5H-benzo[b]thiophene-3-one.
This is achieved by hydrogenation of the compound in the presence of a palladium catalyst.
The hydrogenation is carried out at a pressure of about 50 psi and a temperature of about 50-60°C for several hours.

The next step in the production process is to synthesize 2,9-bis(2-hydroxyethylamino)-1,3:2,4-dibenzo[d,f][1,4]benzoxazepine by treating the reduced compound with a mixture of aqueous sodium hydroxide and hydrogen peroxide.
The reaction is carried out at a temperature of about 50-60°C for several hours, until the reaction is complete.

The final step in the production process is to purify the synthesized compound by dissolving it in water and adjusting the pH to about 3-4.
The compound is then extracted with ethyl acetate, and the organic layer is dried with anhydrous sodium sulfate.
The solvent is then removed under reduced pressure to obtain the pure compound.

2-amino-9-(2-hydroxyethyl)-3H-purin-6-one can also be synthesized by other methods, such as by using bromination, oxidation, and reduction reactions.
However, the above-described method is the most commonly used method for synthesizing the compound.

The production process of 2-amino-9-(2-hydroxyethyl)-3H-purin-6-one is a complex and multi-step process that requires specialized equipment and trained personnel.
However, with the proper equipment and methods, the compound can be synthesized in high yield and purity.
The compound is used in various applications and its demand is expected to increase in the future.