The Production Process of 2-Amino-4-hydroxyquinoline in the Chemical Industry

2-Amino-4-hydroxyquinoline, also known as paracetamol or acetaminophen, is a widely used analgesic and antipyretic drug.
Its production process is a complex chemical reaction that involves several steps.
In this article, we will discuss the production process of 2-amino-4-hydroxyquinoline in the chemical industry.

Step 1: Production of Chloroquinoline

The first step in the production of 2-amino-4-hydroxyquinoline is the production of chloroquinoline.
Chloroquinoline is produced by the reaction of chloral with quinoline.
The reaction is carried out in the presence of an acid catalyst, such as sulfuric acid.
The reaction can be represented as follows:

C6H5Cl + C9H7N → C6H4ClN + C9H7OH

Step 2: Production of N-Acetyl-P-Amino-Benzenamine

Once chloroquinoline is produced, the next step is to convert it into N-acetyl-P-amino-benzenamine.
This is achieved through a series of reactions that involve the reduction of chloroquinoline and the condensation of N-acetyl-anthranilic acid with ammonia.
The reaction can be represented as follows:

C6H4ClN + NH3 + H2O → N-acetyl-P-amino-benzenamine

Step 3: Production of N-Acetyl-P-Amino-Benzenamine Hydrochloride

N-acetyl-P-amino-benzenamine is further converted into N-acetyl-P-amino-benzenamine hydrochloride.
This is achieved by treating N-acetyl-P-amino-benzenamine with hydrochloric acid.
The reaction is exothermic and must be carried out with caution.

N-acetyl-P-amino-benzenamine + HCl → N-acetyl-P-amino-benzenamine HCl

Step 4: Production of 2-Amino-4-hydroxyquinoline

The final step in the production of 2-amino-4-hydroxyquinoline is the conversion of N-acetyl-P-amino-benzenamine hydrochloride into 2-amino-4-hydroxyquinoline.
This is achieved through a series of reactions that involve the oxidation of N-acetyl-P-amino-benzenamine hydrochloride and the addition of hydrogen peroxide.
The reaction can be represented as follows:

N-acetyl-P-amino-benzenamine HCl + H2O2 → 2-amino-4-hydroxyquinoline + H2O

Conclusion

The production process of 2-amino-4-hydroxyquinoline involves several steps, starting from the production of chloroquinoline and ending with the production of 2-amino-4-hydroxyquinoline.
The production process is complex and requires careful control and monitoring to ensure the quality of the final product.
The chemical industry plays a vital role in the production of 2-amino-4-hydroxyquinoline and other important chemicals.
With the right technology and equipment, the production process can be carried out efficiently and safely.