The Production Process of 2-Amino-4,6-dichloro-nicotinicacidmethylester

2-Amino-4,6-dichloro-nicotinic acid methyl ester is a chemical compound that is widely used in various industrial processes.
It is an important intermediate in the production of agrochemicals, pharmaceuticals, and other chemical products.
The production process of 2-amino-4,6-dichloro-nicotinic acid methyl ester involves several steps, which are described in detail below.

Step 1: Preparation of N-Chlorosuccinimide

The first step in the production of 2-amino-4,6-dichloro-nicotinic acid methyl ester involves the preparation of N-chlorosuccinimide.
This compound is prepared by reacting chloroform with succinic acid in the presence of a Lewis acid catalyst, such as AlCl3.
The reaction is exothermic, and it produces N-chlorosuccinimide as a white solid.

Step 2: Condensation of N-Chlorosuccinimide with Sodium Hydroxide

In the second step, N-chlorosuccinimide is condensed with sodium hydroxide to form 4-nitro-2-chlorobenzenesulfonic acid.
This reaction is carried out in the presence of a solvent, such as water or alcohol, and a catalyst, such as hydrochloric acid.
The reaction produces a yellow or greenish-yellow solid, which is filtered and washed with water to remove any impurities.

Step 3: Electrophilic Substitution

In the third step, 4-nitro-2-chlorobenzenesulfonic acid is treated with a base, such as sodium hydroxide or potassium hydroxide, to remove theNO2 group and substitute it with a more reactive electrophile.
The reaction is carried out in the presence of a solvent, such as water or alcohol, and a catalyst, such as hydrochloric acid or sodium hydroxide.
The reaction produces 2-nitro-4-chloro-6-hydroxybenzoic acid, which is a colorless solid.

Step 4: Decarboxylation

In the fourth step, 2-nitro-4-chloro-6-hydroxybenzoic acid is treated with a decarboxylating agent, such as concentrated hydrochloric acid or sulfuric acid.
The reaction is carried out in the presence of a solvent, such as water or alcohol, and a catalyst, such as iron or tin.
The reaction produces 2-amino-4,6-dichloro-nicotinic acid, which is a yellow solid.

Step 5: Methylation

In the final step, 2-amino-4,6-dichloro-nicotinic acid is treated with a methylating agent, such as dimethyl sulfate or methyl iodide, in the presence of a solvent, such as pyridine or dimethylformamide.
The reaction produces 2-amino-4,6-dichloro-nicotinic acid methyl ester, which is a yellow or orange liquid with a distinct odor.

Overall, the production process of 2-amino-4,6-dichloro-nicotinic acid methyl ester involves several steps, including the preparation of N-chlorosuccinimide, condensation with sodium hydroxide, electrophilic substitution, decarboxylation, and methylation.
The intermediate compounds produced in this process are used as building blocks for the synthesis of various agrochemicals, pharmaceuticals, and other chemical products.
However, it is important to note that the production