The Production Process of 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2-PYRIDINYL)ACETONITRILE

2-(6-Chloro-3-pyridazinyl)-2-(2-pyridinyl)acetonitrile is a synthetic chemical compound that is commonly used in various industrial processes.
The production process of this compound involves several steps, each of which requires careful planning and execution to ensure the quality of the final product.
In this article, we will discuss the production process of 2-(6-chloro-3-pyridazinyl)-2-(2-pyridinyl)acetonitrile in detail.

Step 1: Preparation of Raw Materials
The production of 2-(6-chloro-3-pyridazinyl)-2-(2-pyridinyl)acetonitrile begins with the preparation of raw materials.
The key raw material for this compound is 2-pyridinecarboxaldehyde, which is prepared by the following reaction sequence:

Pyridine + Acetaldehyde → Pyridinecarboxaldehyde

Step 2: Wittig Reaction
The next step in the production process involves the Wittig reaction, which is a key step in the synthesis of 2-(6-chloro-3-pyridazinyl)-2-(2-pyridinyl)acetonitrile.
The Wittig reaction involves the reaction of 2-pyridinecarboxaldehyde with a phosphonium ylide, which is prepared from chloroacetyl chloride and dimethyl phosphonate.
The reaction is carried out using a catalyst, such as triphenylphosphine, and yields the desired product.

Step 3: Hydrolysis
The product of the Wittig reaction is then subjected to hydrolysis, which involves the addition of water to the reaction mixture.
This step helps to remove the phosphonate group from the product, which is then isolated by filtration and washed with water.

Step 4: Halogenation
The next step in the production process involves the halogenation of the product from the Wittig reaction.
This is achieved by reacting the product with chloroform and triphenylphosphine in the presence of a catalyst, such as ferric chloride.
The reaction produces the desired halogenated product, which is then isolated by filtration and washed with water.

Step 5: Acylation
The halogenated product is then reacted with acetyl chloride in the presence of a catalyst, such as dicyclohexylamine, to form the acylated product.

Step 6: Desalting
The acylated product is then subjected to desalting, which involves the removal of any impurities that may have been introduced during the previous steps.
This step is important to ensure the purity of the final product.

Step 7: Crystallization
The desalted product is then crystallized, which involves the formation of crystals from the solution.
The crystals are then isolated by filtration and washed with a solvent, such as ethanol.

Step 8: Characterization
The final step in the production process involves the characterization of the product.
This involves various analytical techniques, such as spectroscopy and chromatography, to determine the chemical composition and purity of the final product.

Conclusion
The production process of 2-(6-chloro-3-pyridazinyl)-2-(2-pyridinyl)acetonitrile involves several steps, each of which requires careful planning and execution to ensure the quality of the final product.
The process involves the Wittig reaction, hydrolysis, halogenation, acylation, desalting, crystallization, and characterization.
The product is commonly used in various industrial processes and has various applications in the chemical industry.
The production process outlined in this article is a general guideline and can be modified depending on the specific requirements of the production