The Production Process of 2,5-Pyrrolidinedione, 1-[[(7S,9aS)-octahydro-2-(2-pyrimidinyl)-2H-pyrido[1,2-a]pyrazin-7-yl]methyl]-, hydrochloride (1:1)

The production process of 2,5-Pyrrolidinedione, 1-[[(7S,9aS)-octahydro-2-(2-pyrimidinyl)-2H-pyrido[1,2-a]pyrazin-7-yl]methyl]-, hydrochloride (1:1) involves several steps, from the preparation of raw materials to the final product.
The following is a detailed description of the production process.

Step 1: Preparation of raw materials

The production of 2,5-Pyrrolidinedione, 1-[[(7S,9aS)-octahydro-2-(2-pyrimidinyl)-2H-pyrido[1,2-a]pyrazin-7-yl]methyl]-, hydrochloride (1:1) requires the preparation of several raw materials.
These raw materials include 2-Chloromethyl-3-oxobutane, 7-Amino-1,2,3,4-tetrahydro-2-oxoquinoline, 2-[[(3S)-3-(dimethylamino)propyl]oxy]-5-[[(1R)-1-(methylamino)-1,2,3,4-tetrahydro-2-oxoquinoline-7-yl]oxy]-benzamide, and Hydrochloric acid.
These raw materials are procured from reliable suppliers and are of the highest quality to ensure the production of a high-quality final product.

Step 2: Synthesis of intermediate 1

The first intermediate in the production of 2,5-Pyrrolidinedione, 1-[[(7S,9aS)-octahydro-2-(2-pyrimidinyl)-2H-pyrido[1,2-a]pyrazin-7-yl]methyl]-, hydrochloride (1:1) is synthesized by reacting 2-Chloromethyl-3-oxobutane with 7-Amino-1,2,3,4-tetrahydro-2-oxoquinoline in the presence of a suitable solvent.
The reaction is carried out under controlled temperature and pressure conditions to ensure the desired yield.

Step 3: Synthesis of intermediate 2

The second intermediate in the production of 2,5-Pyrrolidinedione, 1-[[(7S,9aS)-octahydro-2-(2-pyrimidinyl)-2H-pyrido[1,2-a]pyrazin-7-yl]methyl]-, hydrochloride (1:1) is synthesized by reacting intermediate 1 with 2-[[(3S)-3-(dimethylamino)propyl]oxy]-5-[[(1R)-1-(methylamino)-1,2,3,4-tetrahydro-2-oxoquinoline-7-yl]oxy]-benzamide in the presence of a suitable solvent.
The reaction is carried out under controlled temperature and pressure conditions to ensure the desired yield.

Step 4: Synthesis of the final product

The final product, 2,5-Pyrrolidinedione, 1-[[(7S,9aS)-octahydro-2-(2-pyrimidinyl)-2H-pyrido[1,2-a]pyrazin-7-yl]methyl]-, hydrochloride (1:1), is synthesized by reacting intermediate 2 with Hydrochloric acid in the presence of a suitable solvent.
The reaction is carried out under controlled temperature and pressure conditions to ensure the desired yield.

Step 5: Purification and isolation of the final product

After the synthesis of the final product, it is purified and isolated from the reaction mixture using suitable purification methods, such as filtration, distillation, and crystallization.
The purified final product is then dried and ground to the desired particle size.

Step 6: Characterization of the final product

The final product is characterized by various analytical techniques, such as spectroscopy, chromatography, and spectrophotometry