The Production Process of 2-(4-Biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole

2-(4-Biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole, also known as VBZ, is a highly sought-after molecule in the chemical industry due to its unique properties and potential applications.
The production process of VBZ involves several steps, all of which must be carried out with precise precision to ensure the final product meets the required specifications.

Step 1: Synthesis of Biphenyl-4-amine
The first step in the production of VBZ involves the synthesis of Biphenyl-4-amine.
This is done by reacting Phenylamine with Benzaldehyde in the presence of a strong acid catalyst such as Hydrochloric acid.
The reaction is exothermic and requires careful temperature control to avoid unwanted side reactions.

Step 2: Synthesis of 4-tert-Butylphenylboronic Acid
4-tert-Butylphenylboronic Acid is then synthesized by reacting 4-tert-Butylphenol with Bortris(phenylboric acid)acid in the presence of a Lewis acid catalyst such as Aluminum chloride.
This step also requires careful control of the reaction conditions to ensure the desired product is obtained.

Step 3: Synthesis of 2-(4-Biphenylyl)-5-(4-tert-Butylphenyl)-1,3,4-oxadiazole
The final step in the production of VBZ involves the synthesis of the title compound.
This is done by reacting Biphenyl-4-amine and 4-tert-Butylphenylboronic Acid under conditions that allow for the formation of a complex between the two reactants.
The reaction is typically carried out in a solvent such as N,N-Dimethylacetamide or N-Methyl-2-pyrrolidone, and is catalyzed by a compound such as Triphenylphosphine.

Quality Control

Quality control is critical in the production of VBZ to ensure that the final product meets the required specifications.
This involves testing the purity and stability of the product, as well as its chemical properties such as solubility and reactivity.
The results of these tests are used to determine whether the product is suitable for use in various applications.

Production Scale

The production of VBZ on a large scale requires the use of advanced equipment and technology.
This includes reactor systems, distillation columns, and chromatography columns, all of which must be carefully designed and optimized to ensure maximum efficiency and productivity.
The scale of production will also depend on the intended use of the product, with larger scale production required for applications in the chemical industry and pharmaceuticals.

Conclusion

The production of 2-(4-Biphenylyl)-5-(4-tert-Butylphenyl)-1,3,4-oxadiazole is a complex process that requires precise control of the reaction conditions and careful quality control to ensure the final product meets the required specifications.
The use of advanced equipment and technology is essential for large scale production, and the cost of production will depend on the scale of production and the intended use of the product.
Despite these challenges, the high demand for VBZ in the chemical industry and pharmaceuticals makes it a valuable molecule with great potential for a wide range of applications.