The Production Process of 2,3-DIHYDRO-3-OXO-4-PYRIDAZINECARBONITRILE

The production process of 2,3-dihydro-3-oxo-4-pyridazinenitrile, also known as pyridazin-3-carboxamide, is a complex multi-step process that involves several chemical reactions and purification steps.
Pyridazinenitrile is an important intermediate in the production of various chemicals and pharmaceuticals, such as anti-inflammatory drugs, beta-lactam antibiotics, and herbicides.

The production process of pyridazinenitrile can be divided into several stages, including the synthesis of the starting material, the reaction of the starting material to form the intermediate, the reduction of the intermediate, and the purification of the final product.

The synthesis of the starting material, 2,3-dihydro-3-oxo-4-pyridazine, is typically carried out by the reaction of acetamide with chloroform in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction produces the desired 2,3-dihydro-3-oxo-4-pyridazine intermediate, which is then used in the next step of the process.

The next step in the production process is the reaction of the 2,3-dihydro-3-oxo-4-pyridazine intermediate to form the pyridazinenitrile.
This reaction is typically carried out in the presence of a strong base, such as sodium hydroxide, and a solvent, such as water or ethanol.
The reaction produces the desired pyridazinenitrile, which is then used in the reduction step of the process.

In the reduction step of the process, the pyridazinenitrile is reduced to form the final product, 2,3-dihydro-3-oxo-4-pyridazinenitrile.
This reduction is typically carried out using a reducing agent, such as hydrogen gas or sodium borohydride, in the presence of a solvent, such as ethanol or methanol.
The reduction reaction results in the formation of the desired product, which is then purified to remove any impurities.

The purification step of the process typically involves the use of chromatography, such as column chromatography or high-performance liquid chromatography (HPLC).
The purified product is then dried and collected, and any remaining impurities are removed through a series of washing steps.

Overall, the production process of 2,3-dihydro-3-oxo-4-pyridazinenitrile involves several chemical reactions and purification steps.
The process is complex and requires careful control and monitoring to ensure the production of a pure and high-quality product.
The final product is then used as an intermediate in the production of various chemicals and pharmaceuticals.