The Production Process of 2,3-Butanediol, 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)-, methanesulfonate (1:1)

The production process of 2,3-Butanediol, 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)-, methanesulfonate (1:1) involves several steps, including the synthesis of the precursor, the reaction with methanesulfonate, and the isolation of the final product.

Step 1: Synthesis of the Precursor

The first step in the production process of 2,3-Butanediol, 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)-, methanesulfonate (1:1) is the synthesis of the precursor, which involves the reaction of 2,4-difluorophenyl amine with 1H-1,2,4-triazole in the presence of a Lewis acid catalyst, such as aluminum chloride.

The reaction takes place in a suitable solvent, such as a homogeneous mixture of water and ethanol, at a temperature of around 50-60°C.
The reaction mixture is then cooled to room temperature, and the precipitated solid is filtered and washed with water to remove any impurities.

Step 2: Reaction with Methanesulfonate

The next step in the production process of 2,3-Butanediol, 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)-, methanesulfonate (1:1) is the reaction of the precursor with methanesulfonate, which is carried out in the presence of a Lewis acid catalyst, such as sulfuric acid.

The reaction takes place in a suitable solvent, such as ethyl acetate, at a temperature of around 50-60°C.
The reaction mixture is then cooled to room temperature, and the resulting precipitate is filtered and washed with ethyl acetate to remove any impurities.

Step 3: Isolation of the Final Product

The final step in the production process of 2,3-Butanediol, 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)-, methanesulfonate (1:1) is the isolation of the final product, which involves the dissolution of the crude precipitate in a suitable solvent, such as ethyl acetate, and the subsequent crystallization of the product.

The crystallized product is then filtered and washed with ethyl acetate to remove any impurities, and is dried under vacuum to remove any residual solvent.
The final product is then subjected to further purification steps, such as high-performance liquid chromatography (HPLC), to remove any remaining impurities.

Conclusion

The production process of 2,3-Butanediol, 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, (2R,3R)-, methanesulfonate (1:1) involves the synthesis of the precursor, the reaction with methanesulfonate, and the isolation of the final product.
The process requires the use of suitable solvents, Lewis acid catalysts, and purification steps to produce the final product in high purity.