The Production Process of 2,2′-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol]

The production process of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol] involves several steps, starting from the synthesis of the starting materials to the final product.
The following is a detailed description of the production process of this compound.

Step 1: Synthesis of 4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl
The synthesis of 4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl starts with the reaction of 3-ethynylphenylamine with potassium t-butoxide in the presence of a solvent such as THF.
The reaction results in the formation of a tertiary amine, which is then quaternized with methyl iodide to form the quaternary ammonium salt.
The quaternary ammonium salt undergoes a series of reactions, including hydrogenation and Grignard formation, to produce 4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl.

Step 2: Synthesis of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol]
The synthesis of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol] involves the reaction of 4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl with oxetane in the presence of a solvent such as DMF.
The reaction results in the formation of the desired compound.

Step 3: Purification of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol]
After the synthesis of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol], the compound is purified using techniques such as column chromatography or high-performance liquid chromatography (HPLC).
The purification step is necessary to remove any impurities that may have been introduced during the synthesis process.

Step 4: Characterization of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol]
The characterization of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol] is performed using techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and infrared (IR) spectroscopy.
These techniques are used to determine the molecular structure and purity of the compound.

Step 5: Formulation of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol]
After the synthesis and characterization of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinazolinediyl]bis(oxy)]bis[ethanol], the compound is formulated into a final product.
The formulation step involves the addition of excipients, such as buffers or stabilizers, to the compound to produce a stable and soluble form of the drug.

Conclusion
The production process of 2,2'-[[4-[(3-Ethynylphenyl)amino]-6,7-quinaz