The Production Process of 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide

The production process of 2-(1H-indazol-6-ylthio)-N-methylbenzamide, a commonly used organic compound, involves several steps that must be carried out with care and precision to ensure the quality of the final product.

Step 1: Preparation of the starting material
The first step in the production process of 2-(1H-indazol-6-ylthio)-N-methylbenzamide is the preparation of the starting material, which is N-methylbenzamide.
This compound can be synthesized by several methods, including the Grignard reaction, where a metal halide is treated with a base to form a Grignard reagent, which then reacts with benzene to form the desired product.

Step 2: Synthesis of the thiohemiacetal
The next step is the synthesis of the thiohemiacetal, which is formed by the reaction between N-methylbenzamide and thiorphan, a sulfur-containing compound.
This reaction is carried out in the presence of a base, such as sodium hydroxide, to catalyze the formation of the thiohemiacetal.

Step 3: Formation of the indazole ring
The thiohemiacetal obtained from the previous step is then treated with a base, such as sodium hydroxide, to convert it to the corresponding sodium salt.
This salt is then treated with a thiosemicarbazide, such as hydroxylamine, to form the indazole ring.

Step 4: Formation of the benzamide ring
The indazole ring obtained from the previous step is then treated with a benzaldehyde, which reacts with the nitrogen atom of the indazole ring to form the benzamide ring.
This reaction is typically carried out in the presence of an acid catalyst, such as sulfuric acid, to accelerate the reaction.

Step 5: Purification of the product
Finally, the 2-(1H-indazol-6-ylthio)-N-methylbenzamide is separated from the reaction mixture by a process called chromatography, where the solid is passed through a column packed with a solid material, such as silica gel or alumina, that interacts selectively with different components of the mixture.
This allows the pure product to be isolated and collected, while other components of the mixture remain in the column.

In conclusion, the production process of 2-(1H-indazol-6-ylthio)-N-methylbenzamide requires careful planning and execution, and each step must be carried out with precision to ensure the quality of the final product.
The use of advanced technologies, such as chromatography, has made it possible to purify the product to a high degree of purity, ensuring its efficacy and safety in various applications.