The Production Process of 2-(1-Pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

The production process of 2-(1-pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is a complex and multi-step process that involves several intermediate products and reactions.

The process typically begins with the synthesis of the starting material 1,3-dioxolane-2-one, which is then converted into 2-alkoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine.
This intermediate is then reduced to form 2-(1-pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, the final product.

The production process can be broken down into the following steps:

Step 1: Synthesis of 1,3-dioxolane-2-one

The synthesis of 1,3-dioxolane-2-one typically involves the reaction of a derivatives of hydroxybenzaldehyde with an aldehyde in the presence of a base.
The reaction is carried out in a suitable solvent, such as ethanol or methanol, and the product is isolated by filtering the reaction mixture and drying the filtrate.

Step 2: Conversion of 1,3-dioxolane-2-one into 2-alkoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

The conversion of 1,3-dioxolane-2-one into 2-alkoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine typically involves a series of reactions, such as hydrolysis, halogenation, and reduction.
The specific steps involved in this process may vary depending on the manufacturer and the desired product properties.

Step 3: Reduction of 2-alkoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine into 2-(1-pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

The reduction of 2-alkoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine into 2-(1-pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine typically involves the use of a reducing agent, such as lithium aluminum hydride or hydrogen in the presence of a catalyst, such as palladium on coal.
The reduction reaction is carried out in a suitable solvent, such as DMF or THF, and the product is isolated by filtration and washing with a solvent, such as water or ethanol.

Overall, the production process of 2-(1-pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is a complex and multi-step process that involves several intermediate products and reactions.
Each step in the process must be carefully controlled and optimized to ensure the production of a high-quality final product that meets the desired specifications.