The Production Process of 1,6-Dihydro-6-oxo-4-pyridazinecarboxylic acid

The production process of 1,6-dihydro-6-oxo-4-pyridazinecarboxylic acid is a complex and multi-step process that involves several chemical reactions and purification steps.
The process can be broadly classified into five major steps, namely, the preparation of the starting materials, the oxidation step, the nitration step, the reduction step, and the purification step.

Preparation of Starting Materials:
The preparation of the starting materials involves the synthesis of 3-cyanopyridine and 2,4-diamino-6-chloropyrimidine.
3-cyanopyridine can be synthesized by the reaction of ammonia and hydrogen cyanide in the presence of a catalyst, such as zinc chloride.
2,4-diamino-6-chloropyrimidine can be synthesized by the reaction of 2,4-diaminopyrimidine with chloroform and a reactive hydrogen source, such as sodium hydroxide.

Oxidation Step:
The oxidation step involves the oxidation of 3-cyanopyridine to 1,6-dihydro-6-oxo-4-pyridazinecarboxylic acid.
The oxidation can be carried out using various oxidizing agents, such as Potassium permanganate, Ceric sulfate, or Chromium(VI) oxide.
The choice of oxidizing agent depends on the specific requirements of the process, such as the desired yield and purity of the product.

Nitration Step:
The nitration step involves the nitration of 1,6-dihydro-6-oxo-4-pyridazinecarboxylic acid to 1,6-dihydro-6-oxo-4-pyridazinone.
The nitration can be carried out using various nitrating agents, such as Nitric acid, Hydriodic acid, or Nafion-H+.
The choice of nitrating agent depends on the specific requirements of the process, such as the desired yield and purity of the product.

Reduction Step:
The reduction step involves the reduction of 1,6-dihydro-6-oxo-4-pyridazinone to 1,6-dihydro-6-oxo-4-pyridazinecarboxylic acid.
The reduction can be carried out using various reducing agents, such as Lithium aluminum hydride, Hydrogenation, or Sodium borohydride.
The choice of reducing agent depends on the specific requirements of the process, such as the desired yield and purity of the product.

Purification Step:
The purification step involves the purification of the final product to remove any impurities that may have been introduced during the previous steps.
This step can involve the use of various purification techniques, such as crystallization, filtration, and chromatography.
The purification step is critical to the production of a high-quality final product with the desired yield and purity.

Conclusion:
The production process of 1,6-dihydro-6-oxo-4-pyridazinecarboxylic acid involves several chemical reactions and purification steps.
The process can be carried out using various starting materials and reagents, and the choice of reagents depends on the specific requirements of the process, such as the desired yield and purity of the product.
The production process also involves various purification steps to remove any impurities that may have been introduced during the previous steps.
The overall production process requires careful planning and execution to ensure the production of a high-quality final product with the desired yield and purity.