The Production Process of 1-(6-Chloro-pyridazino-3-yl)piperidine

The 1-(6-Chloro-pyridazino-3-yl)piperidine is a type of organic compound that is used in the chemical industry.
The production process of this compound involves a series of chemical reactions that convert the starting materials into the desired product.
The following is a detailed overview of the production process of 1-(6-Chloro-pyridazino-3-yl)piperidine.

Step 1: Synthesis of 2-Chloropyridine
The first step in the production process of 1-(6-Chloro-pyridazino-3-yl)piperidine is the synthesis of 2-chloropyridine.
This compound is synthesized by chlorinating pyridine, which is a basic aromatic compound.
The reaction is carried out in the presence of a Lewis acid catalyst, such as sulfuric acid, to increase the reaction rate.
The reaction is exothermic, and it is essential to remove the heat generated to avoid any undesired side reactions.

Step 2: Condensation of 2-Chloropyridine with N-Phenylpiperazine
The next step in the production process of 1-(6-Chloro-pyridazino-3-yl)piperidine is the condensation of 2-chloropyridine with N-phenylpiperazine.
The reaction is carried out in the presence of a solvent, such as acetonitrile or pyridine, and a coupling agent, such as dicyclohexylcarbodiimide (DCC).
The reaction is catalyzed by a strong acid catalyst, such as hydrochloric acid, to increase the reaction rate.
The reaction produces a N-substituted piperazine, which is then reduced to form the final product.

Step 3: Reduction of N-Substituted Piperazine
The final step in the production process of 1-(6-Chloro-pyridazino-3-yl)piperidine is the reduction of the N-substituted piperazine.
The reduction is carried out using a reducing agent, such as lithium aluminum hydride (LAH), in the presence of a solvent, such as ether or THF.
The reaction is accompanied by the elimination of N-phenylpiperazine from the molecule, resulting in the formation of the final product, 1-(6-Chloro-pyridazino-3-yl)piperidine.

Overall, the production process of 1-(6-Chloro-pyridazino-3-yl)piperidine involves the synthesis of 2-chloropyridine, its condensation with N-phenylpiperazine, and its reduction to form the final product.
The reaction requires the use of various chemicals, solvents, and catalysts to ensure the desired yield and purity of the final product.
The production process is carried out under strict quality control measures to ensure the safety and efficacy of the final product.