The Production Process of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylaMine hydrochloride, 98+% C9H14Cl2N4, MW: 249.14

The Production Process of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylaMine Hydrochloride: An Overview of the Chemical Industry

1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylaMine hydrochloride, with the molecular formula C9H14Cl2N4 and a molecular weight of 249.
14, is an important organic compound that is widely used in various fields such as pharmaceuticals, agrochemicals, and materials science.
The production process of this compound involves several steps, each of which requires careful planning, execution, and monitoring to ensure the quality of the final product.
In this article, we will discuss the production process of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylaMine hydrochloride, highlighting the key steps involved and the challenges that need to be overcome.

Step 1: Synthesis of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylacetic acid
The synthesis of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylacetic acid, which is the starting material for the production of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylaMine hydrochloride, is the first step in the production process.
This compound can be synthesized by several methods, including the reaction of 6-chloropyridazine-3-carboxylic acid with piperidine in the presence of a strong acid catalyst such as sulfuric acid.
The reaction involves the condensation of the two compounds, followed by dehydration to form the desired product.

Step 2: Condensation of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylacetic acid with Hydrochloric Acid
In this step, 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylacetic acid is condensed with hydrochloric acid to form 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylaMine hydrochloride.
This reaction involves the elimination of water molecules from the starting material in the presence of hydrochloric acid, which acts as a catalyst.
The reaction is carried out under controlled conditions to ensure the desired yield and quality of the product.

Step 3: Crystallization
After the condensation reaction, the resulting product is typically impure and contains traces of impurities such as water, organic solvents, and other byproducts.
In order to obtain a pure sample of 1-(6-Chloro-pyridazin-3-yl)-piperidin-4-ylaMine hydrochloride, the product is subjected to crystallization.
This involves dissolving the crude product in a suitable solvent and allowing it to crystallize, after which the crystals are collected, washed, and dried to obtain a pure sample.

Step 4: Purification
The purification step involves the removal of impurities from the crystalline sample obtained in the previous step.
This can be achieved by several methods, including recrystallization, filtration, and chromatography.
In recrystallization, the sample is dissolved in a suitable solvent and allowed to recrystallize, while in filtration, the sample is passed through a filter to remove any impurities.
Chromatography involves the separation of the components of the sample based on their physical and chemical properties, such as size, shape, and solubility.