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    Home > Medical News > Medical World News > The Production Process of 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

    The Production Process of 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

    • Last Update: 2023-05-07
    • Source: Internet
    • Author: User
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    The production process of 1,3-dihydrothiopheno[3,2-d]pyrimidine-2,4-dione is a complex chemical reaction that involves several steps and requires specialized equipment and conditions.
    In the chemical industry, this compound is often used as an intermediate in the production of pharmaceuticals, agrochemicals, and other chemical products.


    The production process of 1,3-dihydrothiopheno[3,2-d]pyrimidine-2,4-dione can be broken down into the following steps:


    1. Raw material preparation: The first step in the production process is to prepare the raw materials that will be used in the reaction.
      These raw materials typically include thiophene-2-carboxylic acid and a substituted aniline, which are mixed together in a solvent such as DMF or DMAc.
    2. Condensation reaction: The next step is to perform a condensation reaction between the two reactants.
      This reaction involves the removal of water from the mixture, which is accomplished by using a condensation agent such as sodium hydroxide or triethylamine.
      The reaction is typically carried out at a temperature of around 100-120°C, and the resulting product is a mixture of 1,3-dihydrothiopheno[3,2-d]pyrimidines.
    3. Dehydration reaction: The next step is to dehydrate the mixture of 1,3-dihydrothiopheno[3,2-d]pyrimidines, which involves removing water from the compound.
      This reaction is typically carried out using a dehydrating agent such as sodium sulfate or calcium chloride, and is typically performed at a temperature of around 120-150°C.
    4. Reductive nitro group elimination: The final step in the production process is to reduce the nitro group of the dehydrated product, which involves the removal of nitrogen gas to form the final product 1,3-dihydrothiopheno[3,2-d]pyrimidine-2,4-dione.
      This reaction is typically carried out using a reducing agent such as lithium aluminum hydride (LAH), which is added to the reaction mixture and heated at a temperature of around 150-180°C.

    In conclusion, the production process of 1,3-dihydrothiopheno[3,2-d]pyrimidine-2,4-dione is a complex chemical reaction that involves several steps and requires specialized equipment and conditions.
    The production process typically involves the preparation of raw materials, a condensation reaction, a dehydration reaction, and a reductive nitro group elimination reaction.
    The final product is a key intermediate in the production of pharmaceuticals, agrochemicals, and other chemical products.


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