The Production Process of 1-(2-Fluoro-phenyl)-3-methyl-butan-1-one

The Production Process of 1-(2-Fluoro-phenyl)-3-methyl-butan-1-one in the Chemical Industry

1-(2-Fluoro-phenyl)-3-methyl-butan-1-one, commonly known as FP-BMA, is a synthetic organic compound used in various applications in the chemical industry.
The compound is used in the production of dyes, fragrances, and other industrial chemicals.
The production process of FP-BMA involves several steps, including the synthesis of the starting materials, the reaction of the starting materials to form the precursor, and the purification of the precursor to obtain the final product.

Synthesis of Starting Materials

The synthesis of the starting materials for the production of FP-BMA involves several steps.
The first step is the synthesis of 2-fluorophenylamine, which is synthesized by treating aniline with fluorine and anhydrous alcohol.
The resulting compound is then treated with sodium hydroxide to remove the fluorine ion, and the resulting compound is isolated by recrystallization.

The second step involves the synthesis of 3-methyl-butan-1-ol, which is synthesized by treating 3-bromopropanol with sodium hydroxide in the presence of water.
The resulting compound is then treated with sodium carbonate and extracted with ethyl acetate to remove the water.
The organic layer is then dried over anhydrous sodium sulfate and the solvent is removed by distillation to obtain the 3-methyl-butan-1-ol.

The third step involves the synthesis of 4-cyanopent-4-enoic acid, which is synthesized by treating formaldehyde with hydrogen cyanide in the presence of sodium hydroxide.
The resulting compound is then treated with methanol to obtain the 4-cyanopent-4-enoic acid.

Reaction of Starting Materials to Form Precursor

The reaction of the starting materials to form the precursor of FP-BMA involves several steps.
The first step involves the reaction of 2-fluorophenylamine and 3-methyl-butan-1-ol in the presence of a Lewis acid catalyst, such as aluminum chloride or ferric chloride.
The reaction conditions include heating the reaction mixture to a temperature of 50-60°C for a period of 8-12 hours.
The resulting compound is then extracted with ethyl acetate and the organic layer is dried over anhydrous sodium sulfate.
The solvent is removed by distillation to obtain the precursor.

Purification of Precursor

The purification of the precursor involves several steps.
The first step involves the addition of water to the precursor and the resulting mixture is then extracted with ethyl acetate.
The organic layer is then washed with water and saturated aqueous sodium bicarbonate and dried over anhydrous sodium sulfate.
The solvent is removed by distillation to obtain the purified precursor.

The final step involves the chemical reaction of the purified precursor with 4-cyanopent-4-enoic acid in the presence of an acid catalyst, such as sulfuric acid or phosphoric acid.
The reaction conditions include heating the reaction mixture to a temperature of 100-110°C for a period of 3-4 hours.
The resulting compound is then extracted with ethyl acetate and the organic layer is dried over anhydrous sodium sulfate.
The solvent is removed by distillation to obtain the final product, 1-(2-Fluoro-phenyl)-3-methyl-butan-1-one, also known as FP-BMA.

Conclusion

The production process of FP-BMA involves several steps, including the synthesis of the starting materials, the reaction of the starting materials to form the precursor, and the purification of the precursor to obtain the final product.
The synthesis of the starting materials requires several steps, including the synthesis of 2-fluorophenylamine, the reaction