The Production Process of 1,1'-THIOCARBONYLDI-2(1H)-PYRIDONE

The production process of 1,1'-thiocarbonldi-2(1H)-pyridone, also known as thiopyridine-2-carboxylate, involves several steps and requires the use of various chemical reagents and equipment.
The following is an overview of the production process of 1,1'-thiocarbonldi-2(1H)-pyridone in the chemical industry.

1. Preparation of raw materials
   The production of 1,1'-thiocarbonldi-2(1H)-pyridone begins with the preparation of raw materials, which includes the reaction of 2-aminopyridine with malonic acid to produce 2-malonicylamino-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine, also known as KHBT.
   This reaction is known as the KHBT reaction.
   
2. Condensation of KHBT with thiophene
   The next step in the production process of 1,1'-thiocarbonldi-2(1H)-pyridone is the condensation of KHBT with thiophene.
   This reaction is carried out in the presence of a solvent such as toluene or xylene, and a condensation agent such as sodium hydroxide or hydrochloric acid.
   The condensation reaction produces 2-cyano-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-6-thiophenylborate, also known as 1,1'-thiocarbonldi-2(1H)-pyridone.
   
3. Hydrolysis of the borate ester
   The next step in the production process of 1,1'-thiocarbonldi-2(1H)-pyridone is the hydrolysis of the borate ester.
   This is carried out by treating the 1,1'-thiocarbonldi-2(1H)-pyridone with water and a strong acid catalyst such as hydrochloric acid.
   The hydrolysis reaction results in the formation of the corresponding carboxylic acid.
   
4. Purification of the carboxylic acid
   After the hydrolysis step, the resulting carboxylic acid is impure and requires purification.
   This is typically achieved through the use of chromatography techniques such as column chromatography or recrystallization.
   
5. Characterization of the product
   Finally, the purified carboxylic acid is characterized to ensure that it meets the desired specifications for use in subsequent applications.
   This characterization may include tests such as nuclear magnetic resonance spectroscopy (NMR) or mass spectrometry.
   

In conclusion, the production process of 1,1'-thiocarbonldi-2(1H)-pyridone involves several steps, including the preparation of raw materials, condensation of KHBT with thiophene, hydrolysis of the borate ester, purification of the carboxylic acid, and characterization of the product.
The process requires the use of various chemical reagents and equipment and is typically carried out in a well-equipped chemical laboratory or industrial facility.