The Production Process of 1,1-Dimethylethyl N-(4-formyl-3-pyridinyl)carbamate

The production process of 1,1-dimethylethyl N-(4-formyl-3-pyridinyl)carbamate involves several steps, each of which requires careful attention to detail and the use of specialized equipment and chemicals.
The following is a detailed overview of the production process for this compound.

Step 1: Preparation of compound 1
To prepare compound 1, 2-(4-formyl-3-pyridinyl)acetamide is used as the starting material.
This compound is first synthesized by reacting 4-aminophenol with acetyl chloride in the presence of a solvent like DMF.
The resulting product is then treated with sodium hydride and the reaction is allowed to proceed at room temperature.

Step 2: Preparation of compound 2
To prepare compound 2, 1,1-dimethylethyl chloride is used as the starting material.
This compound is synthesized by reacting methylene chloride with dimethyl sulfate in the presence of a Lewis acid catalyst like aluminum chloride.
The resulting product is then treated with triethylamine to form the desired compound.

Step 3: Preparation of compound 3
To prepare compound 3, compound 2 is treated with sodium hydride in the presence of a solvent like DMF.
The reaction is allowed to proceed at room temperature and the resulting product is then treated with a solution of 2-(4-formyl-3-pyridinyl)acetamide.

Step 4: Preparation of compound 4
To prepare compound 4, compound 3 is treated with a mineral acid like hydrochloric acid.
The resulting product is then treated with a solution of sodium bicarbonate to neutralize the acid and remove any excess compound 3.
The resulting product is then purified by recrystallization.

Step 5: Preparation of compound 5
To prepare compound 5, compound 4 is treated with a solution of 4-aminophenol in the presence of a solvent like pyridine.
The reaction is allowed to proceed at room temperature and the resulting product is then treated with sodium hydride.

Step 6: Preparation of compound 6
To prepare compound 6, compound 5 is treated with a solution of 2-(4-formyl-3-pyridinyl)acetamide in the presence of a solvent like DMF.
The reaction is allowed to proceed at room temperature and the resulting product is then treated with sodium hydride.

Step 7: Preparation of compound 7
To prepare compound 7, compound 6 is treated with a solution of methylene chloride in the presence of a Lewis acid catalyst like aluminum chloride.
The reaction is allowed to proceed at room temperature and the resulting product is then treated with triethylamine.

Step 8: Preparation of compound 8
To prepare compound 8, compound 7 is treated with a solution of hydrochloric acid.
The resulting product is then treated with sodium bicarbonate and the resulting precipitate is collected by filtration.
The precipitate is then purified by recrystallization.

Step 9: Preparation of compound 9
To prepare compound 9, compound 8 is treated with a solution of 4-aminophenol in the presence of a solvent like pyridine.
The reaction is allowed to proceed at room temperature and the resulting product is then treated with sodium hydride.

Step 10: Preparation of compound 10
To prepare compound 10, compound 9 is treated with a solution of 2-(4-formyl-3-pyridinyl)acetamide in the presence of a solvent