The pace of lupus research has never stopped, and these new discoveries are expected to light up the "healing light"!

"Is there a new cure for it?"

This may be the most concerned issue for butterfly friends, but the advent of any new drug is inseparable from the series of clinical research, trials, and approval for marketi.

Exploring the pathogenesis of lupus can allow clinical researchers to target the "lesions" and accelerate the process of "the road to cur.

Gene mutation leading to loss of function

FcγR IIB is an important receptor on the surface of immune cells, which can bind to IgG-type Fc receptors to exert an immunosuppressive effe.

FcγR IIB acts as a sentinel on the immune defense li.

This discovery provides a new idea for the study of membrane protein transmembrane signal transduction, and is expected to provide a new direction for SLE drug desi.

From this, we can know that the pathogenesis of lupus may be caused by multiple genes, and more than 80 genes related to SLE have been fou.

Programmed death receptor 1

Impaired (PD-1)H function

PD-1 is also an important immunosuppressive molecule, which can inhibit the activity of T cells to regulate the immune system and promote autoimmune toleran.

Gut microbial disturbances

Intestinal flora is an important part of the human body, and many studies have shown that intestinal flora disturbances are closely related to the pathogenesis of S.

At the same time, the study found that probiotics intervention in the treatment of lupus nephritis has certain feasibility , and can provide a new direction for improving the prognosis of lupus nephritis patien.

High-sugar diet

A high-sugar diet induces a significant increase in T-cell activity, making it easier to induce inflammation

Pim-1 gene: lupus

The important mechanism of nephritis pathogenesis

pim-1 kinase is a serine/threonine kinase, encoded by the Pim-1 gene, which controls cell apoptosis, differentiation and proliferati.

At the same time, pim-1 inhibitor can significantly reduce the levels of urinary protein, serum antibodies and renal immune conformers in lupus mi.

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