The operation steps of the four-ring freeze-drying pharmaceutical freeze dryer

After the operation inspection of the four-ring freeze-drying pharmaceutical freeze dryer is completed, the sample entry and freeze dryer operation will be carried out
.

1.
Put the stainless steel bottomless tray on the storage cart and push it to the door of the freeze-drying room of the freeze-drying machine.
During transportation, avoid bumps and bumps to prevent the liquid from splashing on the wall of the vial, which will affect the appearance after freeze-drying
.

2.
Open the freeze-drying compartment door, put the tray into the partition smoothly, slowly pull out the tray, and insert the sample probe into the sample respectively
.

3.
After the sample is placed, check whether the freeze-drying compartment door is closed and whether there is a gap on the side
.

4.
Check whether the cold trap door is closed and whether the water inside the cold trap has been wiped clean.
If there is water, it should be drained and wiped clean
.

So as not to affect the life of the vacuum pump
.

 5: After checking and confirming that there is no problem, click the program freeze-drying button on the main page to enter the freeze-drying curve setting page
.

 6: After setting the freeze-drying curve, press the manual button on the left side of the freeze-drying program, the freeze-drying machine will enter the automatic operation mode, and enter the sublimation drying stage after the pre-freezing stage
.

After the sublimation drying stage, it will transfer to the analytical drying stage
.

After the analytical drying operation is completed, it is judged that the sample has been dried by the sample temperature and vacuum degree
.

Manual tamping under vacuum using an external lift handle
.

After the rubber stopper is pressed, exit the automatic operation state, close the compressor, circulation pump, vacuum pump, and cold trap valve, open the backfill valve to fill the freeze-drying chamber with clean air, and then open the chamber door to take out the sample package.

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 The freeze-drying process is a heat and mass transfer process involving refrigeration, vacuum, electronics, chemistry, cryogenic medicine and other disciplines with high technical content and complex freeze-drying process
.

In the pharmaceutical industry, pharmaceutical freeze dryers play an important role, which can reduce the possibility of material being oxidized and deteriorate, eliminate bacteria in the material, ensure that the original shape of the material can be well preserved, and further reduce the risk of contamination, At present, it is suitable for drying of raw materials, Chinese medicine decoction pieces, biology, pharmaceutical intermediates and other materials
.

In recent years, with the continuous development of the pharmaceutical industry, Sihuan freeze-drying pharmaceutical freeze-dryers have also continued to strengthen technological innovation, promote greater breakthroughs in equipment, and be better used in the pharmaceutical drying industry
.