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The Oncologist: The relationship between HER2 gene changes and microsatellite instability (MSI-H) in colorectal adenocarcinoma

 Last Update: 2021-05-21
 Source: Internet
 Author: User

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Colorectal cancer (CRC) ranks fourth in incidence and fifth in mortality among malignant tumors in China.

Include patients who have undergone next-generation sequencing (NGS) from 2017.

Patient clinical characteristics

Mutation type

The median progression-free period (DFS) of patients with HER2 genetic changes was 17.

DFS analysis

Twenty-five patients with MSI-H received PD-1 monoclonal antibody treatment, of which 9 had HER2 mutations and 16 had no HER2 changes.

Anti-PD1 treatment for DFS

In summary, the proportion of MSI-H found in HER2 mutation cases is higher, but MSI-H is not found in HER2 amplified cases.

Original source:

ncbi.

ncbi.
nlm.
nih.
gov/?term=Qiu+MZ&cauthor_id=33844372">Miao-Zhen Qiu , ncbi.
nlm.
nih.
gov/?term=He+CY&cauthor_id=33844372">Cai-Yun He , ncbi.
nlm.
nih.
gov/?term=Yang+XH&cauthor_id=33844372">Xin-Hua Yang ,et al.
Relationship of HER2 Alteration and Microsatellite Instability Status in Colorectal Adenocarcinoma.
Oncologist.
2021 Apr 12.
doi: 10.
1002/onco.
13786.
Online ahead of print.
ncbi.
nlm.
nih.
gov/?term=Qiu+MZ&cauthor_id=33844372">Miao -Zhen Qiu ncbi.
nlm.
nih.
gov/?term=He+CY&cauthor_id=33844372">Cai-Yun He ncbi.
nlm.
nih.
gov/?term=Yang+XH&cauthor_id=33844372">Xin-Hua Yang leaves a message here

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