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According to the latest global cancer data released by the academic journal CA: A Cancer Journal for Clinicians, in 2020, there were 19.
29 million new cancer cases worldwide and 9.
96 million cancer deaths.
This staggering number means that although the global socio-economic development has increased substantially in the past decade, and the level of medical care and treatment methods have also been continuously improved, the rapid increase in cancer incidence and related deaths cannot be stopped.
The fight against cancer has a long way to go.
At present, the 5-year survival rate of patients with advanced cancer is still very low.
One of the main reasons is the cancer stem cells in the tumor.
These cells not only are resistant to radiotherapy and chemotherapy, but also hide or circulate in the body, leading to cancer recurrence.
Recently, in a new study published in "Nature Biomedical Engineering" (IF=19), a research team led by Professor Shinya Tanaka from Hokkaido University in Japan has developed an innovative hydrogel that can dissolve 6 Different types of human cancer cell lines are transformed into cancer stem cells.
This research result will pave the way for the development of new cancer therapies and personalized medicines targeting cancer stem cells.
In 2012, for his research on "somatic cell reprogramming technology", Shinya Yamanaka, then a professor at Kyoto University in Japan, won the Nobel Prize in Physiology or Medicine that year.
Cancer Stem Cell (CSC), also known as cancer stem cell, refers to cells in tumors that have the ability to self-renew and produce heterogeneous tumor cells.
It is known that cancer stem cells play an important role in tumor deterioration and resistance to treatment.
The corresponding author of the study and Professor Shinya Tanaka of the Faculty of Medicine of Hokkaido University explained: "Cancer stem cells are the main targets of anti-cancer drugs, but they are difficult to identify because they are very small in tumor tissues.
Understanding the molecular mechanisms of cancer stem cells is essential for the development of better cancer therapies.
"It is known that cancer stem cells require a very special microenvironment.
In this study, the researchers investigated whether their new hydrogel can recreate a suitable environment for inducing cancer stem cells.
This new type of hydrogel is called double Network hydrogels (Double-Network hydrogels), a network composed of two chemical substances, and contain a large amount of water, making it have soft and moisturizing properties similar to biological tissues.
In this study, double-network hydrogels Within 24 hours, differentiated cancer cells from 6 different human cancer cell lines (brain cancer, uterine cancer, lung cancer, colon cancer, bladder cancer and sarcoma) were rapidly reprogrammed into cancer stem cells.
The cancer cells were placed in the double network water.
On the gel, they begin to form spherical structures and produce specific molecules known to be cancer stem cell markers, such as SOX2 and Oct3/4 and Nanog, indicating that they have been reprogrammed.
Human brain cancer cells are formed on the double network hydrogel Compared with brain cancer cells cultured on single network gel, the spherical structure of human brain cancer cells cultured on double network hydrogel and intracranially injected into immunodeficient mice has higher tumorigenicity.
In addition, The researchers identified some molecular mechanisms involved in the reprogramming of cancer cells.
They found that calcium channel receptors and osteopontin (osteopontin) are the keys to inducing cancer stem cells.
They also found that brain cancer cells from patients are coagulated in a double network.
After being cultured on the gel, receptors called platelet-derived growth factors are produced.
By adding molecular inhibitors of these receptors, they can target the elimination of cancer stem cells, which shows that the double network hydrogel can be used to select therapeutic drugs .
Tanaka said: "this paves the way for the study of drugs capable of targeting cancer stem cells.
In the future, the dual-network hydrogel can be used to optimize the diagnosis of cancer cell types and develop personalized medicines, thereby improving the prognosis of cancer patients.
"The link to the paper: 2020 hot articles selection 1.
The cup is full! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
American, British and Australian scientists "Natural Medicine" add another proof: the new coronavirus is a natural evolution product, or it has two origins.
.
.
3.
NEJM: The effect of intermittent fasting on health, aging and disease 4.
Cure insomnia within one year! Research finds : To improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: "Crawling in nature" 28 days of "rolling" is enough to improve immunity 7.
Junk food is "real rubbish"! It takes away the length of telomeres and makes people age faster! 8.
Cell puzzle: you can die if you don't sleep! But The fatal changes do not occur in the brain, but in the intestines.
.
.
9.
"Nature Communications" ultra-large-scale study: the level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reverse the "permanent" brain damage in animals overnight , It also restores the youthful state of the old brain.
.
.
29 million new cancer cases worldwide and 9.
96 million cancer deaths.
This staggering number means that although the global socio-economic development has increased substantially in the past decade, and the level of medical care and treatment methods have also been continuously improved, the rapid increase in cancer incidence and related deaths cannot be stopped.
The fight against cancer has a long way to go.
At present, the 5-year survival rate of patients with advanced cancer is still very low.
One of the main reasons is the cancer stem cells in the tumor.
These cells not only are resistant to radiotherapy and chemotherapy, but also hide or circulate in the body, leading to cancer recurrence.
Recently, in a new study published in "Nature Biomedical Engineering" (IF=19), a research team led by Professor Shinya Tanaka from Hokkaido University in Japan has developed an innovative hydrogel that can dissolve 6 Different types of human cancer cell lines are transformed into cancer stem cells.
This research result will pave the way for the development of new cancer therapies and personalized medicines targeting cancer stem cells.
In 2012, for his research on "somatic cell reprogramming technology", Shinya Yamanaka, then a professor at Kyoto University in Japan, won the Nobel Prize in Physiology or Medicine that year.
Cancer Stem Cell (CSC), also known as cancer stem cell, refers to cells in tumors that have the ability to self-renew and produce heterogeneous tumor cells.
It is known that cancer stem cells play an important role in tumor deterioration and resistance to treatment.
The corresponding author of the study and Professor Shinya Tanaka of the Faculty of Medicine of Hokkaido University explained: "Cancer stem cells are the main targets of anti-cancer drugs, but they are difficult to identify because they are very small in tumor tissues.
Understanding the molecular mechanisms of cancer stem cells is essential for the development of better cancer therapies.
"It is known that cancer stem cells require a very special microenvironment.
In this study, the researchers investigated whether their new hydrogel can recreate a suitable environment for inducing cancer stem cells.
This new type of hydrogel is called double Network hydrogels (Double-Network hydrogels), a network composed of two chemical substances, and contain a large amount of water, making it have soft and moisturizing properties similar to biological tissues.
In this study, double-network hydrogels Within 24 hours, differentiated cancer cells from 6 different human cancer cell lines (brain cancer, uterine cancer, lung cancer, colon cancer, bladder cancer and sarcoma) were rapidly reprogrammed into cancer stem cells.
The cancer cells were placed in the double network water.
On the gel, they begin to form spherical structures and produce specific molecules known to be cancer stem cell markers, such as SOX2 and Oct3/4 and Nanog, indicating that they have been reprogrammed.
Human brain cancer cells are formed on the double network hydrogel Compared with brain cancer cells cultured on single network gel, the spherical structure of human brain cancer cells cultured on double network hydrogel and intracranially injected into immunodeficient mice has higher tumorigenicity.
In addition, The researchers identified some molecular mechanisms involved in the reprogramming of cancer cells.
They found that calcium channel receptors and osteopontin (osteopontin) are the keys to inducing cancer stem cells.
They also found that brain cancer cells from patients are coagulated in a double network.
After being cultured on the gel, receptors called platelet-derived growth factors are produced.
By adding molecular inhibitors of these receptors, they can target the elimination of cancer stem cells, which shows that the double network hydrogel can be used to select therapeutic drugs .
Tanaka said: "this paves the way for the study of drugs capable of targeting cancer stem cells.
In the future, the dual-network hydrogel can be used to optimize the diagnosis of cancer cell types and develop personalized medicines, thereby improving the prognosis of cancer patients.
"The link to the paper: 2020 hot articles selection 1.
The cup is full! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
American, British and Australian scientists "Natural Medicine" add another proof: the new coronavirus is a natural evolution product, or it has two origins.
.
.
3.
NEJM: The effect of intermittent fasting on health, aging and disease 4.
Cure insomnia within one year! Research finds : To improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: "Crawling in nature" 28 days of "rolling" is enough to improve immunity 7.
Junk food is "real rubbish"! It takes away the length of telomeres and makes people age faster! 8.
Cell puzzle: you can die if you don't sleep! But The fatal changes do not occur in the brain, but in the intestines.
.
.
9.
"Nature Communications" ultra-large-scale study: the level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reverse the "permanent" brain damage in animals overnight , It also restores the youthful state of the old brain.
.
.
