The new research of Su Zhong's group helps to clarify the pathogenesis of cerebral malaria

According to Guangzhou Institute of biomedicine and health, Chinese Academy of Sciences, a new study carried out by Suzhong research group using mouse malaria model shows that immunomodulatory B cells play an important role in the control of cerebral malaria The results were published in the European Journal of immunology According to reports, malaria is one of the three major infectious diseases in the world The main pathological changes caused by Plasmodium infection include severe anemia, multiple organ failure and cerebral malaria Although it is known that cerebral malaria is caused by excessive immune response, the mechanism of its immune regulation has not been fully understood In recent years, immunology research has found that there is a subpopulation of B cells, regulatory B cells, which has the function of immunoregulation and inhibition These regulatory B cells play an important role in immunomodulatory function by secreting cytokine IL-10, and in inhibiting excessive immune response and controlling immunopathology The researchers found that the regulatory B cells that secrete IL-10 in the spleen cells of mice infected with Plasmodium significantly increased Cell transfer experiments showed that regulatory B cells could significantly inhibit the recruitment of NK and CD8 + T cells in brain tissue, inhibit the pathological changes of microvascular hemorrhage in brain tissue, and significantly reduce the mortality of malaria infected mice Further studies showed that regulatory B cells can significantly promote the differentiation of CD4+T cells and secretion of IL-10, and confirmed that regulatory B cells inhibit the occurrence of cerebral malaria is mediated by IL-10 Relevant experts said that the results are not only of great significance to clarify the pathogenesis of cerebral malaria, but also provide an important theoretical basis for the formulation of prevention and intervention strategies and the development of anti malaria drugs.