The new protein research project is expected to completely eliminate the fatal infectious diseases

Gary bookoch and his colleagues are on the front line against some of the most terrible enemies that humans have ever known: tuberculosis, pneumonia, Ebola, plague, botulism But he wasn't in a hospital or in a field tent, getting vital signs or giving medication Instead, Gary bookoch's biochemists are in the lab, and the front line is the world of proteins - molecules that make all living things work and make life possible Using a number of high-tech methods, he worked with scientists in the Northwest Pacific region to find important information about the need to develop better treatments or vaccines for many infectious diseases that can cause pain, nausea, fatigue, food poisoning, diarrhea, ulcers, dyspnea and death As a member of the Seattle Center for structural genomics of infectious diseases, and one of the two centers funded by the National Institute of allergy and infectious diseases, Gary bookoch is responsible for solving the protein structure that enables pathogens to survive, reproduce and infect humans The research comes from the joint efforts of scientists from four institutions: the infectious diseases research center, beryllium research and development company, the University of Washington, and the Pacific Northwest National Laboratory of the Department of energy, which conducts research in buchko Solve infectious diseases - one protein at a time, Garry buchko and colleagues, use NMR to solve the structure of proteins, which are usually transmitted by ticks The team reached a milestone by announcing that its scientists have solved the three-dimensional structure of the 1000th protein from more than 70 organisms that cause infectious diseases in the human body The team studied proteins from microbes that cause several serious diseases, including tuberculosis, Listeria, Giardia, Ebola virus, anthrax, C diff infection, Legionella, Lyme disease, chlamydia infection and influenza Although the proteins isolated for research are not pathogenic, structural information provides scientists with the opportunity to design molecules that will knock out the necessary processes in these microorganisms This is challenging work The shape of the protein is very complex, many people look like curly wheels, with multiple twists, bends and loops, all of which are squeezed into one tenth of the width of human hair The arrangement and length of these characteristics make each protein have specific biochemical characteristics Understanding the precise shape of proteins provides a blueprint for scientists to find new ways to disable pathogens and prevent diseases they may cause Gary bookoch and his colleagues explained the structure of the malaria causing protein found in organisms Gary bookoch's specialty is MRI or MRI, which is very similar to the MRI technology widely used by doctors to diagnose various medical conditions Gary bookoch uses nuclear magnetic resonance technology to check the protein of pathogens in the Environmental Molecular Science Laboratory of EMSL and the environmental analysis science laboratory of PNNL science user facility office Although the final result is an atomic image, it is not as simple as capturing a picture Instead, Gary bookoch placed the protein in an NMR spectrometer and recorded information about the orientation, energy, and other properties of all the nuclei in the molecule He then interprets the information and feeds thousands of pieces of data into a computer program to calculate the position of each atom, leading to a complete 3-D reconstruction of the protein Data analysis is very important for correct structure Gary bookoch has been the author of the team's research for more than 20 years over the past decade His goal is to cause tuberculosis, malaria, the pathogen of haemorrhagic fever, and the waterborne parasite that causes severe diarrhea and abdominal pain A protein in microorganisms causes eosinophilia, most commonly in people in tropical climates When contaminated dust or soil is inhaled, the infection usually begins in the lungs SSGCID scientists published more than 100 manuscripts detailing their findings In addition, all structures are immediately shared with the scientific community through a public database called the protein database As a result, these structures have been used in nearly 600 scientific papers from academic circles, research institutions and other laboratories of pharmaceutical companies that are studying human pathogens around the world Sharing its findings so that scientists around the world can further discover them is at the heart of SSGCID's mission The center in Seattle is one of two centers funded by NIAID (Contract No hhsn272201200025c) Another, based in Chicago, is the center for structural genomics of infectious diseases, which includes another DOE laboratory, Argonne National Laboratory SSGCID is led by Peter MYLER, professor and head of core services, infectious diseases research center "When SSGCID solves the protein structure, it lays the foundation for CID research and researchers around the world to find new drug, treatment and vaccine candidates for diseases that kill thousands of people every year," MYLER said "I'm proud of the hard work our team and our loyal partners have done."