The new mechanism of immune response helps suppress the new coronavirus.

The University of Waterloo in Canada says it has discovered a new immune response mechanism that can use specialty drugs to significantly enhance the defense and antiviral effects of the body's immune system, playing a key role in the treatment of viral diseases such as neo-pneumonia and AIDS, as well as other diseases such as cancerone of the current research hotspots for the new coronavirus is drug reuse research, but the treatment of existing drugs has limited effect sharply and has obvious side effects, and the pathology of neo-coronapneumonia is not really understood, so it is difficult to find a successful clinical special effects druglead research professor, DrLu Qingbin, of the University of Waterloo, systematically studied several key biological processes of reactive oxygen (ROS), active halogens (RHS) and active nitrogen (RNS)These processes play a critical physiological role, including why the need for superoxide dismutase (the enzyme that catalyzes H2O2 formation - SOD) from cell metabolism, why the amount of ROS/RNS produced by the clinically used ionizing radiation dose is approximately 1000 times lower than the amount of endogenous ROS/RNS produced in normal cell metabolism, and why a small amount of endogenous RHS can play a key role in immune protection in phagonasylLu Qingbin proposed a potential amplification mechanism in immune defense: the same active halogen cycle reaction that causes the destruction of the ozone layer enhances the RHS immune defense effect, resulting in the above three important physiological functionsThese functions are activated by the H2O2 signal molecule and inactivated by the NO signal moleculeLu Qingbin proposed the immune defense system against pathogens is composed of three parts: H2O2 signal conduction path is a "trigger", the active halogen reaction cycle is "amplifier", and the NO signal conduction path is "terminator"The delicate balance between the H2O2 and NO signaling pathways produces the desired immune effect, giving multicellular organisms sufficient biological defenses against the invasion of viruses or other foreign organisms, while being sufficiently resistant to allergies andautoimmunediseasesWith this new immune response mechanism, Lu Qingbin believes that the drugs found on this basis can be safer (without side effects) and more effectively promote the immune system to fight the virusresults show that the reaction cycle of active halogens can be repeated thousands of times in the body's immune response, thus amplifying the effect of RHS killing pathogens (defenses) by 100,000 times in phagocytosisThis is very similar to the RHS cycle reaction that creates a huge ozone hole in the atmosphere"With this new knowledge, we can use new and effective compounds to replace drugs with serious side effects, greatly improve the effectiveness of the immune system, help it fight aggressive viruses and treat the diseases it produces, as well as treat other diseases such as aging and cancer," saidLu Qingbin research was published in the June 2020 issue of Cell (
Bio valley Bioon.com) .