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The new crown is "yang", what is the role of vitamin C?

 Last Update: 2023-02-03
 Source: Internet
 Author: User

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Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin that is recommended among the anti-inflammatory drugs in the "New Coronary Pneumonia Diagnosis and Treatment Plan Treatment Drug Information Collection (Second Edition)
".
So after the adjustment of epidemic prevention and control measures, with the menacing of positive patients, what is the role of vitamin C in drug treatment? How to administer medication?

Pharmacological effects^[1]
participate in amino acid metabolism, neurotransmitter synthesis, collagen and histocellular interstitium synthesis, can reduce capillary permeability, accelerate blood clotting, stimulate coagulation function, Promote iron absorption in the intestine, promote the decline of blood lipids, increase resistance to infection, participate in detoxification function, and have the effect of antihistamine and preventing the production of carcinogens (nitrosamines).

Reference dosage
for "new coronary pneumonia" 1.
Infusion regimen for light and ordinary new coronary pneumonia: 2g added to 5% glucose injection 250mL, intravenous drip, once a day, 7-14 days 1 course of treatment
.

2.
When the disease progresses to mild and ordinary patients and there is a risk of turning into severe disease: 50-100mg per day kg-1, intravenous drip
.

3.
“ Prevention and control of cytokine storm": 100-200 mg per day kg-1, intravenously
.
The goal is a significant improvement in the oxygenation index during the period of continuous use
.
For the dosage of off-label medication
.

【Source of evidence】1.

The National Health Commission's "On Printing and Distributing the Management Standards for Light and Common Cases of Novel Coronavirus Pneumonia (Second Edition)" mentions the infusion scheme
for mild and ordinary new coronary pneumonia.

2.
The "Shanghai 2019 Coronavirus Disease Comprehensive Treatment Expert Consensus" mentions that if the disease progresses significantly and there is a risk of turning into severe disease, high-dose vitamin C treatment
is recommended.
In addition, the prevention and treatment of "cytokine storm" recommends the use of higher doses of vitamin C
.

3.
Zhongnan Hospital of Wuhan University registered and applied for "a randomized, open, parallel-controlled clinical study evaluating the efficacy and safety of enteric-coated capsules of diammonium glycyrrhizinate combined with vitamin C tablets in the treatment of common novel coronavirus pneumonia (COVID-19) on the basis of clinical standard antiviral therapy".

Among them, the dosage of vitamin C tablets is 0.
5g, and the drug is taken once
a day.

4.
UpToDate: Vitamin C as an antioxidant, used in the adjuvant treatment of various acute and chronic infectious diseases, has been widely used in the treatment of sepsis, combined with hydrocortisone can act synergistically on the inflammatory cascade
.

Other clinical applications ^[2-7].

Scurvy: used for the treatment of scurvy, can also be used for various acute and chronic infectious diseases and purpura and other auxiliary treatment
.
For the prevention and treatment of
vitamin C deficiency.
Keshan disease: high-dose intravenous injection is used for Keshan disease, rescue in cardiogenic shock
.
Chronic iron poisoning: Vitamin C promotes the chelation of iron by deferoxamine, which accelerates iron excretion
.
Idiopathic methemoglobinosis: treatment
of idiopathic methemoglobinosis.
Enhance resistance: enhance the body's resistance, used to prevent and treat various acute and chronic infectious diseases or other diseases
.
Wound healing: used for post-illness recovery period, wound healing period and adjuvant treatment
of allergic diseases.

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The "evidence-based medicine" module you want is the 👇 dry drug decision assistant

References:

[1] None.
Compilation of new coronary pneumonia diagnosis and treatment plan treatment drug information (second edition)[J].
Zhongnan Pharmacy,2020,18(3):14.
)

[2] Drug information: vitamin C injection, Heilongjiang Gerun Pharmaceutical Co.
, Ltd.
, Sinopharm H20058721
.

[3] Drug information: vitamin C for injection, CSPC Ouyi Pharmaceutical Co.
, Ltd.
, Sinopharm H20053380
.

[4] Drug information: vitamin C chewable tablets, Changchun Dirui Pharmaceutical Co.
, Ltd.
, Sinopharm H22025676
.

[5] Drug information: vitamin C effervescent tablets, Bayer Healthcare Co.
, Ltd.
, Sinopharm H20056946, 2017/06/05
.

[6] Drug information: Vitamin C tablets, Northeast Pharmaceutical Group Shenyang First Pharmaceutical Co.
, Ltd.
, Sinopharm H21020713
.

[7] Drug information: vitamin C pills, Jilin Yatai Yong'an Tang Pharmaceutical Co.
, Ltd.
, Sinopharm H22020684
.

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