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| University of Birmingham study: The new coronavirus causes the immune system of patients to attack their own tissues or organs |
Since the outbreak of the new crown epidemic, there are still many unanswered questions about the clinical manifestations of patients
.
Previous observations have found that COVID-19 is related to a variety of unexpected symptoms, including Guillain-Barré syndrome and myocardial pericarditis, whether during treatment after diagnosis or several months after discharge
It is not fully understood what causes these symptoms, but scientists have proposed a possibility that the new coronavirus triggers an autoimmune process that causes the immune system to be misled and attack itself instead
.
According to the official website of the University of Birmingham in the United Kingdom, a new study led by the school found that many COVID-19 patients have an immune response that attacks their own tissues or organs
This study was recently published in Clinical & Experimental Immunology.
The research team is from the University of Birmingham.
The corresponding author is Alex G.
Richter, a professor at the Institute of Immunology and Immunotherapy of the University of Birmingham and an honorary consultant in clinical immunology
.
According to the official website of the University of Birmingham, Richter has been leading a team of experts from the University of Birmingham to develop a SARS-CoV-2 antibody test
This latest study investigated 84 patients with COVID-19, including COVID-19 patients who were in a severe phase at the time of testing, severe patients who were in recovery, and mild patients who did not need to be hospitalized
.
The results of the patient's study were compared with 32 control groups, who received intensive care for reasons other than COVID-19
Autoantibody is an antibody (a protein) produced by the immune system.
It directly targets one or more of the individual's own proteins and can cause autoimmune diseases
.
In some cases, infection can cause autoimmune diseases
The new study completed by Richter and colleagues found that the number of autoantibodies in COVID-19 patients is higher than that in the control group, and these antibodies last up to 6 months
.
Compared with the control group, it was also found that the autoantibodies of non-new coronavirus infections were more diverse.
The research team also found that from the blood, patients with severe COVID-19 are more likely to have autoantibodies
.
Professor Richter explained, "The antibodies we found are similar to those that cause multiple autoimmune diseases of the skin, muscle, and heart
.
"
She said, “We don’t know whether these autoantibodies actually cause symptoms in patients, or whether this is a common phenomenon after infection, or just after COVID-19
.
These problems will be in our next research.
Professor David Cameron Wraith, one of the authors of the paper and Director of the Institute of Immunology and Immunotherapy at the University of Birmingham, added, “In this detailed study of a series of different tissues, we have shown for the first time that COVID-19 infection is associated with selective autoantibodies.
It is relevant
.
” He believes that more research is needed to determine whether these antibodies will cause the long-term consequences of SARS-CoV-2 infection, so that targeted treatment can be carried out
.
