The near-atomic resolution structure of human herpes virus has been analyzed

Recently, the National Research Center for Microscale Material Science of The University of Science and Technology of China, Professor Bi Guoqiang of the School of Life Sciences, Professor Zhou Zhenghong of the University of California, Los Angeles, and Mei Wei Researcher of East China Normal University, in cooperation with Mei Wei Researcher, analyzed the near-atomic resolution structure of the human herpes virus type 6B for the first time by using high-resolution cryoscopic single particle analysis technology. The findings were published online in nature-newsletter.
Human Herpes Virus Type 6 (HHV-6) belongs to the herpes virus family β Herpes virus sub-family, according to its surface antigen, but also divided into HHV-6A and HHV-6B two closely related virus types. Many young children will be infected with HHV-6 virus, and may have fever, diarrhea, red rash and other clinical symptoms;
, the HHV-6 virus has even been linked to Alzheimer's disease and epilepsy. HHV-6 virus infection causes widespread harm, but there is currently no high-resolution structure of the virus, as well as structure-based drugs or vaccine antiviral programs. Due to its high bonding with host cells, HHV-6B is difficult to achieve in-body proliferation culture, which has become a major problem in the analysis of atomic resolution structure.
For this reason, the team used advanced cryoscopic direct electronic counting techniques and subparticle local reconstruction methods to reveal at the atomic level the structure of compounds in different herpes viruses to assist the virus casing in coping with internal pressures from different genome sizes, helping to better understand the packaging of the β herpes virus genome and viral nuclear shell stabilization mechanism, improve the understanding of the family structure of herpes virus, enrich and deepen the understanding of β herpes virus and even the entire herpes virus family shell complex function mechanism
(Source: Yang Fan, China Science Daily)