The natural drug Genkwadaphnin blocks cholesterol synthesis and inhibits the development of liver cancer.

Wen: As one of the main causes of cancer-related deaths worldwide, HCC patients have a five-year survival rate of only 15%, and more than 80% of HCC patients are diagnosed with advanced and poor prognosis.
growing evidence that liver cancer occurs not only with genetic and genomic changes, but also with changes in metabolism.
, in-depth understanding of the relevant molecular basis of HCC, and the development of effective treatment strategies, is very conducive to improving patient survival.
Causes of Liver Cancer Viral Hepatitis (50%): Epidemiological statistics show that the prevalence of hepatitis B is also a high incidence of liver cancer, people with hepatitis B than people who have not had hepatitis B are 10 times more likely to develop liver cancer.
alcohol (35%): As the saying goes, "drinking hurts the liver", drinking alcohol is not the direct cause of liver cancer, but it acts like a catalyst to promote the occurrence and progression of liver cancer.
dietary factors (15%): the occurrence of liver cancer is closely related to lifestyle.
long-term consumption of mildew food, nitrosamine-containing food, trace element selenium deficiency is also an important factor in the development of liver cancer.
Overall, the cause of primary liver cancer has not been fully clarified, but has been shown to be closely related to the following factors: 1, viral hepatitis: long-term clinical observation found that hepatitis, cirrhosis, liver cancer is a migrating evolution of the trilogy.
recent studies have shown that viral hepatitis associated with liver cancer mainly includes hepatitis B (HBV) and hepatitis C (BCV), of which hepatitis B is the most common.
2, alcohol: have long-term alcohol addiction is easy to induce liver cancer.
This is because alcohol enters the body, mainly in the liver to break down metabolism, alcohol toxicity to liver cells make liver cells on fatty acids decomposition and metabolism obstacles, resulting in fat deposition in the liver and resulting in fatty liver.
drink alcohol, the more severe the fatty liver, which in turn leads to liver fibrosis, cirrhosis, liver cancer.
if hepatitis patients drink heavily, it will greatly accelerate the formation and development of cirrhosis and promote the occurrence of liver cancer.
3, dietary factors: aflatoxin B1 has been shown to have a clear carcinogenic effect, mainly in moldy food, such as corn, peanuts, rice and so on.
In addition, when eating a large number of food containing nitrites, nitrite accumulation in the body can not be discharged in time, can be converted into nitrosamines in the body, nitrite content of higher food to smoke or salted meat products mainly, with a clear carcinogenic effect.
the occurrence of liver cancer is also related to genetic factors, parasitic infections and other factors.
aboutliver is a central organ that regulates the steady state of cholesterol, DHCR24 is a key enzyme in the biosynthetic pathway of cholesterol and is involved in the formation of lipid rafts.
(Genkwadaphnin, GD) is a kind of rhyme diazole isolated from the buds of the Thymelaeaceae plantflowers.
: The chemical structure of GD We used HCC cells and BALB/c naked mouse models to evaluate the role of GD, identified the difference expression gene in GD by gene chip, and detected the expression and activity of DHCR24, cholesterol levels, lipid raft structure, and the role of DHCR24 in liver cancer samples, we found that in liver cancer samples, the high expression level of DHCR24 was closely related to the patient's poor prognosis.
interference with the expression of DHCR24 can inhibit the growth and migration of HCC cells.
GD dosing inhibits the growth and metastasis of HCC cells and ultimately inhibits the invasion and migration of HCC cells by inhibiting the expression and activity of DHCR24 and the biosynthetic process and lipid raft formation of DHCR24-mediated cholesterol.
Figure: Difference gene expression map of GD treatment: GD inhibits liver cancer development related schematic summary Summary, our data show that targeted DHCR24 mediated cholesterol metabolism may be an effective treatment strategy for liver cancer, and natural product GD may become a potential drug for HCC treatment.
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