The modernization of traditional Chinese medicine and the resplendence of Cordyceps sinensis mycelium extract in the treatment of lung disease

Pulmonary fibrosis is a kind of end-stage changes of lung diseases characterized by fibroblast proliferation, a large number of extracellular matrix aggregation and inflammatory damage, tissue structure destruction That is to say, normal alveolar tissue is damaged and then leads to structural abnormality (scar formation) after abnormal repair Most of the patients with pulmonary fibrosis have unknown etiology (idiopathic) This group of diseases is called idiopathic interstitial pneumonia (IIP), which is a large class of interstitial lung diseases The most common type of pulmonary fibrosis in idiopathic interstitial pneumonia (IIP) is idiopathic pulmonary fibrosis (IPF), which can lead to progressive loss of lung function Pulmonary fibrosis seriously affects the respiratory function of human body, which is manifested as dry cough, progressive dyspnea (conscious insufficiency of Qi), and with the aggravation of disease and lung injury, the respiratory function of patients is deteriorating The incidence rate and mortality rate of idiopathic pulmonary fibrosis increase year by year The average survival time after diagnosis is only 2.8 years The mortality rate is higher than most tumors, and is called a kind of "tumor like disease" When lung injury is caused by various reasons, collagen will be secreted by the stroma for repair If over repair, that is, excessive proliferation of fibroblasts and a large number of extracellular matrix accumulation, pulmonary fibrosis will be formed Air pollution, smoking, viral and bacterial infections, as well as genetic problems, can cause lung damage and fibrosis Pulmonary fibrosis usually occurs in 40-50 years old, and in males it occurs in females Dyspnea is the most common symptom of pulmonary fibrosis In mild pulmonary fibrosis, dyspnea often occurs in severe activities, so it is often ignored or misdiagnosed as other diseases When pulmonary fibrosis progresses, dyspnea also occurs at rest Patients with severe pulmonary fibrosis may have progressive dyspnea Other symptoms include dry cough and fatigue Some patients have clubbing fingers and cyanosis The serious consequences of pulmonary fibrosis lead to the change of normal lung tissue structure and loss of function When a large number of fibrotic tissues without gas exchange function replace alveoli, oxygen cannot enter the blood Patients with poor breathing, anoxia, acidosis, loss of labor, serious cases can eventually lead to death The treatment mainly includes drug treatment and non drug treatment At present, only western medicine pirfenidone is available in China Because of the high cost and side effects of pirfenidone, the effect of pirfenidone on slowing down the progress of disease is not ideal Therefore, the treatment of pirfenidone in IPF is not recommended Non drug therapy mainly includes ① oxygen therapy ② Mechanical ventilation ③ Lung recovery ④ Lung transplantation Therefore, western medicine and Western medicine have no good way to prevent and reverse pulmonary fibrosis Traditional Chinese medicine has a unique effect on the prevention and treatment of chronic diseases Cordyceps sinensis, a precious Chinese herbal medicine in traditional Chinese medicine, is used in the treatment of various lung diseases The main effective ingredients of Cordyceps sinensis powder (trichospora batifolia mycelium) are ten times higher than that of natural Cordyceps sinensis, and the price is only one tenth of that of natural Cordyceps The research team of Professor Hou Yayi of Nanjing University found that the extract of trichospora batmoth mycelium could significantly reduce the expression of TNF - α, IL-1 β, TGF - β 1, TIMP1 and MMP9 in lung tissue, improve the inflammatory change of lung tissue, and decrease the expression of α - SMA and fibronection in lung and interstitium It was revealed that Cordyceps mycelium extract has the function of regulating immunity and improving pulmonary fibrosis, and the mechanism of improving pulmonary fibrosis was revealed for the first time Conclusion the results show that the mycelium extract of trichospora batmoth has the functions of inhibiting inflammation, balancing immunity and alleviating pulmonary fibrosis.