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Recently, Prof.
Cao Sujiao, a full-time postdoctoral fellow in the Department of Ultrasound Medicine of our hospital, is the first author of the paper.
Figure 1: Journal Cover
Nature has created a large number of biological enzymes to catalyze various biochemical reactions and biological processes
Since it is not possible to compare the catalytic activity, substrate selectivity, kinetics and reactive oxygen species (ROS) production of different M-Nx single-atom centers, and to analyze the related catalytic ROS production mechanism, etc.
Figure 2: Metalloprotease-like single-atom library materialscatalyzing the production of ROS
Figure 3: Structural characterization of transition metal single-atom enzyme mimics
Figure 4: Catalytic ROS production activityof single-atom enzyme-mimicking materials
Theoretical calculation results show that the catalytic pathway and activity of AMEs are closely related to the electronic structure of the metal active center
Figure 5: Pathway and theoretical analysis of catalytic ROS production activity
In this study, for the first time, 20 single-atom libraries of ROS-catalyzing metalloproteinases with regular nanocube morphology, consistent size and specific surface area but different metal centers were synthesized, and the enzyme centers of related single-atom materials were systematically analyzed and compared.
Original link: https://onlinelibrary.
