The mechanism of tumor micro-environment regulation of immune cell function is revealed

research team at Huahua University of Science and Technology revealed the mechanism by which tumor cells and immune cells regulate each other in the tumor micro-environment. The results were published online recently in the Journal of Clinical Research.
recent years, with the clinical success of tumor immunotherapy, especially Car-T cell immunotherapy technology and immune node therapy, in-depth study of tumor micro-environment has important basic research significance for the regulation mechanism of immune cell function.
In mouse models, tumor cells transplanted from the skin grew faster, pulmonary adenocarcinoma tumor cells in the tail intravenously transferred nods to the lungs increased significantly in mice, blood vessels increased, and macrophages increased to promote tumor esophageal polarization, according to a team study by Yang Yiping of the Department of Immunology at Hua zhong University of Science and Technology.
Yang and the pathology team WangPing found that in human clinical pulmonary adenocarcinoma patients' tissues, tumor cells can regulate the expression of macrophage follicle hydrase through their metabolites, so that tumor-related macrophages in the tumor microenviron environment programmatically recombined to promote tumor growth of immune cells.
the study also found that the expression of cystic hydrolysase can be used as an important prognostic marker for pulmonary adenocarcinoma, and therefore has important clinical significance. (Source: Xinhua News Agency, Li Wei)